Detailed information of TA system TA044239

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 217573..217830
• Replicon: chromosome
• Accession: NZ_AP027957
• Organism: Escherichia coli strain VE-T10

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: V0YDF1
• Locus tag: QQK14_RS01060
• Protein ID: WP_001135738.1
• Coordinates: 217678..217830 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	217573..217627 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QQK14_RS01040	212798..213793	-	996	WP_001182653.1	O-acetyltransferase WecH	-
QQK14_RS01045	213968..214267	+	300	WP_000980104.1	YsaB family lipoprotein	-
QQK14_RS01050	214362..215273	+	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
QQK14_RS01055	215283..217352	+	2070	WP_001291774.1	glycine--tRNA ligase subunit beta	-
-	217573..217627	-	55	-	-	Antitoxin
QQK14_RS01060	217678..217830	+	153	WP_001135738.1	type I toxin-antitoxin system toxin HokA	Toxin
QQK14_RS01065	217819..217878	-	60	WP_212591412.1	hypothetical protein	-
QQK14_RS01070	218018..218230	-	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
QQK14_RS01075	218511..218801	-	291	WP_000455798.1	HTH-type transcriptional regulator	-
QQK14_RS01080	219235..219945	+	711	WP_000190517.1	DUF3053 domain-containing protein	-
QQK14_RS01085	219995..220969	-	975	WP_000805027.1	glyoxylate/hydroxypyruvate reductase GhrB	-
QQK14_RS01090	221073..221732	-	660	WP_000747625.1	OmpA family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5912.14 Da
• Isoelectric Point: 7.7173

>T44239 WP_001135738.1 NZ_AP027957:217678-217830 [Escherichia coli]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGSYELAAFLACNLKE

Nucleotide

• Length: 153 bp

>T44239 NZ_AP027957:217678-217830 [Escherichia coli]
ATGCCGCAGAAATATAGATTACTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCATTTTTAGCCTGCAATTTAAAAGAGTAA

Antitoxin

Nucleotide

• Length: 55 bp

>AT44239 NZ_AP027957:c217627-217573 [Escherichia coli]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A7U9LX93

Antitoxin