44214

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 760432..761125 Replicon chromosome
Accession NZ_AP027953
Organism Escherichia coli strain VE-F5

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag QQJ99_RS03690 Protein ID WP_000415584.1
Coordinates 760432..760728 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag QQJ99_RS03695 Protein ID WP_000650107.1
Coordinates 760730..761125 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQJ99_RS03655 (755520) 755520..755834 - 315 WP_000958598.1 putative quinol monooxygenase -
QQJ99_RS03660 (755865) 755865..756446 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
QQJ99_RS03665 (756765) 756765..757097 + 333 WP_000917685.1 DUF2645 family protein -
QQJ99_RS03670 (757143) 757143..758492 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
QQJ99_RS03675 (758489) 758489..759148 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
QQJ99_RS03680 (759300) 759300..759692 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
QQJ99_RS03685 (759745) 759745..760227 + 483 WP_000183505.1 GyrI-like domain-containing protein -
QQJ99_RS03690 (760432) 760432..760728 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
QQJ99_RS03695 (760730) 760730..761125 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
QQJ99_RS03700 (761258) 761258..762865 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
QQJ99_RS03705 (763003) 763003..765261 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T44214 WP_000415584.1 NZ_AP027953:760432-760728 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T44214 NZ_AP027953:760432-760728 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT44214 WP_000650107.1 NZ_AP027953:760730-761125 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT44214 NZ_AP027953:760730-761125 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References