Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4214251..4214509 Replicon chromosome
Accession NZ_AP027926
Organism Escherichia fergusonii strain 30038

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag QUE84_RS20215 Protein ID WP_000809168.1
Coordinates 4214357..4214509 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4214251..4214308 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE84_RS20190 4210054..4210995 - 942 WP_000767329.1 bifunctional riboflavin kinase/FAD synthetase -
QUE84_RS20195 4211003..4211221 - 219 WP_001300728.1 DUF2575 family protein -
QUE84_RS20200 4211324..4211587 + 264 WP_001274021.1 30S ribosomal protein S20 -
QUE84_RS20205 4211683..4212582 - 900 WP_000019049.1 transcriptional activator NhaR -
QUE84_RS20210 4212650..4213816 - 1167 WP_046076806.1 Na+/H+ antiporter NhaA -
- 4214251..4214308 - 58 - - Antitoxin
QUE84_RS20215 4214357..4214509 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
QUE84_RS20220 4214613..4215743 - 1131 WP_001118464.1 molecular chaperone DnaJ -
QUE84_RS20225 4215832..4217748 - 1917 WP_000516135.1 molecular chaperone DnaK -
QUE84_RS20230 4218256..4218822 + 567 WP_000528529.1 acetate uptake transporter -
QUE84_RS20235 4218856..4219443 - 588 WP_223689159.1 molybdopterin adenylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T44174 WP_000809168.1 NZ_AP027926:4214357-4214509 [Escherichia fergusonii]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T44174 NZ_AP027926:4214357-4214509 [Escherichia fergusonii]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT44174 NZ_AP027926:c4214308-4214251 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References