Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 2147551..2148059 | Replicon | chromosome |
| Accession | NZ_AP027734 | ||
| Organism | Agromyces marinus strain NBRC 109019 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | - |
| Locus tag | QUE48_RS10890 | Protein ID | WP_234659980.1 |
| Coordinates | 2147799..2148059 (+) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | - |
| Locus tag | QUE48_RS10885 | Protein ID | WP_234659981.1 |
| Coordinates | 2147551..2147802 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUE48_RS10830 (GCM10025870_22570) | 2142765..2143013 | + | 249 | WP_234659991.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| QUE48_RS10835 (GCM10025870_22580) | 2143010..2143267 | + | 258 | WP_234659990.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| QUE48_RS10840 (GCM10025870_22590) | 2143321..2143668 | - | 348 | WP_234659989.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| QUE48_RS10845 (GCM10025870_22600) | 2143662..2143907 | - | 246 | WP_234659988.1 | ribbon-helix-helix domain-containing protein | - |
| QUE48_RS10850 (GCM10025870_22620) | 2144606..2144821 | + | 216 | WP_234659987.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| QUE48_RS10855 (GCM10025870_22630) | 2144818..2145222 | + | 405 | WP_234659986.1 | VapC toxin family PIN domain ribonuclease | - |
| QUE48_RS10860 (GCM10025870_22640) | 2145273..2145509 | - | 237 | WP_234659985.1 | hypothetical protein | - |
| QUE48_RS10865 (GCM10025870_22650) | 2145709..2145837 | + | 129 | WP_267963239.1 | hypothetical protein | - |
| QUE48_RS10870 (GCM10025870_22660) | 2145897..2146400 | - | 504 | WP_234659984.1 | hypothetical protein | - |
| QUE48_RS10875 (GCM10025870_22670) | 2146455..2146949 | - | 495 | WP_234659983.1 | hypothetical protein | - |
| QUE48_RS10880 (GCM10025870_22680) | 2147037..2147450 | + | 414 | WP_234659982.1 | hypothetical protein | - |
| QUE48_RS10885 (GCM10025870_22690) | 2147551..2147802 | + | 252 | WP_234659981.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| QUE48_RS10890 (GCM10025870_22700) | 2147799..2148059 | + | 261 | WP_234659980.1 | Txe/YoeB family addiction module toxin | Toxin |
| QUE48_RS10895 | 2148507..2148710 | - | 204 | Protein_2146 | PIN domain-containing protein | - |
| QUE48_RS10900 (GCM10025870_22720) | 2148786..2149328 | - | 543 | WP_234659978.1 | helix-turn-helix domain-containing protein | - |
| QUE48_RS10905 (GCM10025870_22730) | 2149411..2149980 | - | 570 | WP_234659977.1 | hypothetical protein | - |
| QUE48_RS10910 (GCM10025870_22740) | 2150184..2150447 | + | 264 | WP_234659976.1 | ribbon-helix-helix protein, CopG family | - |
| QUE48_RS10915 (GCM10025870_22750) | 2150444..2150683 | + | 240 | WP_234659975.1 | BrnT family toxin | - |
| QUE48_RS10920 (GCM10025870_22760) | 2150728..2150958 | - | 231 | WP_234659974.1 | hypothetical protein | - |
| QUE48_RS10925 (GCM10025870_22770) | 2151085..2151597 | - | 513 | WP_234659973.1 | barstar family protein | - |
| QUE48_RS10930 (GCM10025870_22780) | 2151699..2152415 | + | 717 | WP_234659972.1 | DUF2071 domain-containing protein | - |
| QUE48_RS10935 (GCM10025870_22790) | 2152469..2152888 | + | 420 | WP_234659971.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2144818..2164592 | 19774 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 10183.53 Da Isoelectric Point: 7.3146
>T44142 WP_234659980.1 NZ_AP027734:2147799-2148059 [Agromyces marinus]
VTRALAFDQNGWEDYVYWQTQDRKTLRRINVLIADVLRDPFAGIGKPEPLKHILSGAWSRRIDETNRLVYYVTDDHIVIL
QARDHY
VTRALAFDQNGWEDYVYWQTQDRKTLRRINVLIADVLRDPFAGIGKPEPLKHILSGAWSRRIDETNRLVYYVTDDHIVIL
QARDHY
Download Length: 261 bp
>T44142 NZ_AP027734:2147799-2148059 [Agromyces marinus]
GTGACCCGCGCGCTCGCGTTCGATCAGAACGGCTGGGAGGACTACGTCTACTGGCAGACGCAAGACCGCAAGACGCTCAG
ACGGATCAACGTCCTGATCGCCGACGTGCTCCGTGACCCGTTCGCCGGCATCGGGAAGCCGGAGCCGCTCAAGCACATCC
TTTCGGGTGCGTGGTCTCGCCGCATCGACGAGACGAATCGGCTCGTCTACTACGTCACGGACGACCACATCGTCATCCTG
CAAGCCCGCGACCACTATTGA
GTGACCCGCGCGCTCGCGTTCGATCAGAACGGCTGGGAGGACTACGTCTACTGGCAGACGCAAGACCGCAAGACGCTCAG
ACGGATCAACGTCCTGATCGCCGACGTGCTCCGTGACCCGTTCGCCGGCATCGGGAAGCCGGAGCCGCTCAAGCACATCC
TTTCGGGTGCGTGGTCTCGCCGCATCGACGAGACGAATCGGCTCGTCTACTACGTCACGGACGACCACATCGTCATCCTG
CAAGCCCGCGACCACTATTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9257.30 Da Isoelectric Point: 4.8210
>AT44142 WP_234659981.1 NZ_AP027734:2147551-2147802 [Agromyces marinus]
MSAITATEARKSLFGLIQQVNDDHTAVEVVSRHGNAVIMSKDDYDAITETAHLLRNPANAERLLDAIERARRGEFEQHDL
LEA
MSAITATEARKSLFGLIQQVNDDHTAVEVVSRHGNAVIMSKDDYDAITETAHLLRNPANAERLLDAIERARRGEFEQHDL
LEA
Download Length: 252 bp
>AT44142 NZ_AP027734:2147551-2147802 [Agromyces marinus]
ATGTCGGCAATCACCGCGACCGAGGCGCGCAAGAGCCTGTTCGGCCTGATCCAGCAGGTCAACGACGATCACACCGCAGT
CGAGGTCGTCTCTCGACACGGCAACGCCGTGATCATGTCGAAGGACGACTACGACGCGATCACGGAGACCGCTCACTTGC
TGCGCAACCCTGCCAACGCCGAGCGGCTCCTCGACGCGATCGAGCGGGCGCGTCGCGGCGAGTTCGAGCAGCACGACCTC
CTCGAAGCGTGA
ATGTCGGCAATCACCGCGACCGAGGCGCGCAAGAGCCTGTTCGGCCTGATCCAGCAGGTCAACGACGATCACACCGCAGT
CGAGGTCGTCTCTCGACACGGCAACGCCGTGATCATGTCGAAGGACGACTACGACGCGATCACGGAGACCGCTCACTTGC
TGCGCAACCCTGCCAACGCCGAGCGGCTCCTCGACGCGATCGAGCGGGCGCGTCGCGGCGAGTTCGAGCAGCACGACCTC
CTCGAAGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|