Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 62117..62381 Replicon plasmid pEC556_1
Accession NZ_AP027439
Organism Escherichia coli strain EC556 isolate EC556

Toxin (Protein)


Gene name pndA Uniprot ID U9Y6M3
Locus tag QUE77_RS01175 Protein ID WP_001331364.1
Coordinates 62117..62269 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 62319..62381 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE77_RS01155 (60087) 60087..60296 - 210 WP_286338356.1 HEAT repeat domain-containing protein -
QUE77_RS01160 (60705) 60705..60881 + 177 WP_001054900.1 hypothetical protein -
QUE77_RS01165 (60946) 60946..61041 - 96 WP_001303310.1 DinQ-like type I toxin DqlB -
QUE77_RS01170 (61794) 61794..62045 + 252 WP_001291964.1 hypothetical protein -
QUE77_RS01175 (62117) 62117..62269 - 153 WP_001331364.1 Hok/Gef family protein Toxin
- (62319) 62319..62381 + 63 NuclAT_0 - Antitoxin
- (62319) 62319..62381 + 63 NuclAT_0 - Antitoxin
- (62319) 62319..62381 + 63 NuclAT_0 - Antitoxin
- (62319) 62319..62381 + 63 NuclAT_0 - Antitoxin
QUE77_RS01180 (62561) 62561..63769 + 1209 WP_286338357.1 IncI1-type conjugal transfer protein TrbA -
QUE77_RS01185 (63788) 63788..64859 + 1072 Protein_68 IncI1-type conjugal transfer protein TrbB -
QUE77_RS01190 (64852) 64852..67144 + 2293 Protein_69 F-type conjugative transfer protein TrbC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..88955 88955


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5775.13 Da        Isoelectric Point: 8.7948

>T44069 WP_001331364.1 NZ_AP027439:c62269-62117 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T44069 NZ_AP027439:c62269-62117 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 63 bp

>AT44069 NZ_AP027439:62319-62381 [Escherichia coli]
TCGAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5W9M382

Antitoxin

Download structure file

References