Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4321781..4322038 Replicon chromosome
Accession NZ_AP027423
Organism Escherichia coli strain EC261 isolate EC261

Toxin (Protein)


Gene name hokA Uniprot ID V0YDF1
Locus tag QUE58_RS23570 Protein ID WP_001135738.1
Coordinates 4321781..4321933 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokA
Locus tag -
Coordinates 4321984..4322038 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE58_RS23540 4317879..4318538 + 660 WP_000747625.1 OmpA family lipoprotein -
QUE58_RS23545 4318642..4319616 + 975 WP_094317554.1 glyoxylate/hydroxypyruvate reductase GhrB -
QUE58_RS23550 4319666..4320376 - 711 WP_000190517.1 DUF3053 domain-containing protein -
QUE58_RS23555 4320810..4321100 + 291 WP_000455798.1 HTH-type transcriptional regulator -
QUE58_RS23560 4321381..4321593 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
QUE58_RS23565 4321733..4321792 + 60 WP_212591412.1 hypothetical protein -
QUE58_RS23570 4321781..4321933 - 153 WP_001135738.1 type I toxin-antitoxin system toxin HokA Toxin
- 4321984..4322038 + 55 - - Antitoxin
QUE58_RS23575 4322259..4324328 - 2070 WP_001291774.1 glycine--tRNA ligase subunit beta -
QUE58_RS23580 4324338..4325249 - 912 WP_001168544.1 glycine--tRNA ligase subunit alpha -
QUE58_RS23585 4325344..4325643 - 300 WP_000980104.1 YsaB family lipoprotein -
QUE58_RS23590 4325818..4326813 + 996 WP_001182653.1 O-acetyltransferase WecH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5912.14 Da        Isoelectric Point: 7.7173

>T43971 WP_001135738.1 NZ_AP027423:c4321933-4321781 [Escherichia coli]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGSYELAAFLACNLKE

Download         Length: 153 bp

>T43971 NZ_AP027423:c4321933-4321781 [Escherichia coli]
ATGCCGCAGAAATATAGATTACTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCATTTTTAGCCTGCAATTTAAAAGAGTAA

Antitoxin


Download         Length: 55 bp

>AT43971 NZ_AP027423:4321984-4322038 [Escherichia coli]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LX93

Antitoxin

Download structure file

References