Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 565122..565380 Replicon chromosome
Accession NZ_AP027423
Organism Escherichia coli strain EC261 isolate EC261

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag QUE58_RS05200 Protein ID WP_000809168.1
Coordinates 565122..565274 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 565323..565380 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE58_RS05180 560363..561076 - 714 WP_001102379.1 acidic protein MsyB -
QUE58_RS05185 561102..561506 - 405 WP_000843559.1 DUF2541 family protein -
QUE58_RS05190 561883..563799 + 1917 WP_000516135.1 molecular chaperone DnaK -
QUE58_RS05195 563888..565018 + 1131 WP_001118464.1 molecular chaperone DnaJ -
QUE58_RS05200 565122..565274 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 565323..565380 + 58 - - Antitoxin
QUE58_RS05205 565860..567026 + 1167 WP_000681368.1 Na+/H+ antiporter NhaA -
QUE58_RS05210 567092..567991 + 900 WP_001300855.1 transcriptional activator NhaR -
QUE58_RS05215 568030..568988 - 959 Protein_523 fimbrial family protein -
QUE58_RS05220 569001..570332 - 1332 Protein_524 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T43940 WP_000809168.1 NZ_AP027423:c565274-565122 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T43940 NZ_AP027423:c565274-565122 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTAGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT43940 NZ_AP027423:565323-565380 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATAGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References