Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 107051..107305 | Replicon | plasmid pEC261_2 |
| Accession | NZ_AP027421 | ||
| Organism | Escherichia coli strain EC261 isolate EC261 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | G9G1E3 |
| Locus tag | QUE58_RS01040 | Protein ID | WP_001312851.1 |
| Coordinates | 107051..107200 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | srnC | ||
| Locus tag | - | ||
| Coordinates | 107244..107305 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUE58_RS01010 (102333) | 102333..105338 | + | 3006 | WP_001143760.1 | Tn3-like element Tn3 family transposase | - |
| QUE58_RS01015 (105271) | 105271..105736 | - | 466 | Protein_96 | plasmid replication initiator RepA | - |
| QUE58_RS01020 (105729) | 105729..106211 | - | 483 | WP_001273588.1 | hypothetical protein | - |
| QUE58_RS01025 (106204) | 106204..106251 | - | 48 | WP_229471593.1 | hypothetical protein | - |
| QUE58_RS01030 (106242) | 106242..106493 | + | 252 | WP_223195197.1 | replication protein RepA | - |
| QUE58_RS01035 (106510) | 106510..106767 | - | 258 | WP_000083845.1 | replication regulatory protein RepA | - |
| QUE58_RS01040 (107051) | 107051..107200 | - | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
| - (107244) | 107244..107305 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (107244) | 107244..107305 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (107244) | 107244..107305 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (107244) | 107244..107305 | + | 62 | NuclAT_1 | - | Antitoxin |
| QUE58_RS01045 (107561) | 107561..107635 | - | 75 | Protein_102 | endonuclease | - |
| QUE58_RS01050 (107880) | 107880..108092 | - | 213 | WP_001299730.1 | ANR family transcriptional regulator | - |
| QUE58_RS01055 (108228) | 108228..108788 | - | 561 | WP_000139315.1 | fertility inhibition protein FinO | - |
| QUE58_RS01060 (108891) | 108891..109751 | - | 861 | WP_000704513.1 | alpha/beta hydrolase | - |
| QUE58_RS01065 (109810) | 109810..110556 | - | 747 | WP_000205749.1 | conjugal transfer pilus acetylase TraX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | sitABCD / tet(A) / sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B | iutA / iucD / iucC / iucB / iucA / iroB / iroC / iroD / iroE / iroN / vat | 1..138688 | 138688 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T43931 WP_001312851.1 NZ_AP027421:c107200-107051 [Escherichia coli]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T43931 NZ_AP027421:c107200-107051 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 62 bp
>AT43931 NZ_AP027421:107244-107305 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
