Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 3864179..3864681 | Replicon | chromosome |
| Accession | NZ_AP027411 | ||
| Organism | Escherichia coli strain EC521 isolate EC521 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | QUE69_RS19175 | Protein ID | WP_000767829.1 |
| Coordinates | 3864427..3864681 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | A0A2S1Y4D6 |
| Locus tag | QUE69_RS19170 | Protein ID | WP_001259254.1 |
| Coordinates | 3864179..3864430 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUE69_RS19145 (3859357) | 3859357..3860424 | - | 1068 | WP_016232166.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| QUE69_RS19150 (3860424) | 3860424..3861494 | - | 1071 | WP_000108986.1 | histidinol-phosphate transaminase | - |
| QUE69_RS19155 (3861491) | 3861491..3862795 | - | 1305 | WP_046788605.1 | histidinol dehydrogenase | - |
| QUE69_RS19160 (3862801) | 3862801..3863700 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| QUE69_RS19165 (3863846) | 3863846..3863896 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| QUE69_RS19170 (3864179) | 3864179..3864430 | + | 252 | WP_001259254.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| QUE69_RS19175 (3864427) | 3864427..3864681 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| QUE69_RS19180 (3864764) | 3864764..3865588 | + | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| QUE69_RS19185 (3865634) | 3865634..3866563 | + | 930 | WP_213831478.1 | LysR substrate-binding domain-containing protein | - |
| QUE69_RS19190 (3866778) | 3866778..3866840 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| QUE69_RS19195 (3866830) | 3866830..3868188 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| QUE69_RS19200 (3868366) | 3868366..3869424 | + | 1059 | WP_000492313.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| QUE69_RS19205 (3869438) | 3869438..3869665 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T43849 WP_000767829.1 NZ_AP027411:3864427-3864681 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T43849 NZ_AP027411:3864427-3864681 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9292.57 Da Isoelectric Point: 4.5822
>AT43849 WP_001259254.1 NZ_AP027411:3864179-3864430 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGIGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGIGTEKD
IIE
Download Length: 252 bp
>AT43849 NZ_AP027411:3864179-3864430 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCATAGGAACAGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCATAGGAACAGAAAAGGAC
ATTATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|