Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2644134..2644827 Replicon chromosome
Accession NZ_AP027411
Organism Escherichia coli strain EC521 isolate EC521

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag QUE69_RS13360 Protein ID WP_000415584.1
Coordinates 2644134..2644430 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag QUE69_RS13365 Protein ID WP_000650107.1
Coordinates 2644432..2644827 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE69_RS13325 (2639222) 2639222..2639536 - 315 WP_000958598.1 putative quinol monooxygenase -
QUE69_RS13330 (2639567) 2639567..2640148 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
QUE69_RS13335 (2640467) 2640467..2640799 + 333 WP_000917684.1 DUF2645 family protein -
QUE69_RS13340 (2640845) 2640845..2642194 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
QUE69_RS13345 (2642191) 2642191..2642850 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
QUE69_RS13350 (2643002) 2643002..2643394 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
QUE69_RS13355 (2643447) 2643447..2643929 + 483 WP_000183505.1 GyrI-like domain-containing protein -
QUE69_RS13360 (2644134) 2644134..2644430 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
QUE69_RS13365 (2644432) 2644432..2644827 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
QUE69_RS13370 (2644960) 2644960..2646567 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
QUE69_RS13375 (2646705) 2646705..2648963 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T43845 WP_000415584.1 NZ_AP027411:2644134-2644430 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T43845 NZ_AP027411:2644134-2644430 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT43845 WP_000650107.1 NZ_AP027411:2644432-2644827 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT43845 NZ_AP027411:2644432-2644827 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References