Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3805731..3806424 Replicon chromosome
Accession NZ_AP027408
Organism Escherichia coli strain EC507 isolate EC507

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag QUE45_RS19955 Protein ID WP_000415584.1
Coordinates 3806128..3806424 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag QUE45_RS19950 Protein ID WP_000650107.1
Coordinates 3805731..3806126 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE45_RS19940 (3801595) 3801595..3803853 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
QUE45_RS19945 (3803991) 3803991..3805598 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
QUE45_RS19950 (3805731) 3805731..3806126 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
QUE45_RS19955 (3806128) 3806128..3806424 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
QUE45_RS19960 (3806629) 3806629..3807111 - 483 WP_000183489.1 GyrI-like domain-containing protein -
QUE45_RS19965 (3807164) 3807164..3807556 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
QUE45_RS19970 (3807708) 3807708..3808367 + 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
QUE45_RS19975 (3808364) 3808364..3809713 + 1350 WP_000673357.1 quorum sensing histidine kinase QseC -
QUE45_RS19980 (3809759) 3809759..3810091 - 333 WP_000917684.1 DUF2645 family protein -
QUE45_RS19985 (3810410) 3810410..3810991 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
QUE45_RS19990 (3811022) 3811022..3811336 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T43834 WP_000415584.1 NZ_AP027408:c3806424-3806128 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T43834 NZ_AP027408:c3806424-3806128 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT43834 WP_000650107.1 NZ_AP027408:c3806126-3805731 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT43834 NZ_AP027408:c3806126-3805731 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References