Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1356769..1357462 Replicon chromosome
Accession NZ_AP027404
Organism Escherichia coli strain EC416 isolate EC416

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag QUE37_RS07495 Protein ID WP_000415584.1
Coordinates 1356769..1357065 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag QUE37_RS07500 Protein ID WP_000650107.1
Coordinates 1357067..1357462 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE37_RS07460 (1351857) 1351857..1352171 - 315 WP_000958598.1 putative quinol monooxygenase -
QUE37_RS07465 (1352202) 1352202..1352783 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
QUE37_RS07470 (1353102) 1353102..1353434 + 333 WP_000917684.1 DUF2645 family protein -
QUE37_RS07475 (1353480) 1353480..1354829 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
QUE37_RS07480 (1354826) 1354826..1355485 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
QUE37_RS07485 (1355637) 1355637..1356029 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
QUE37_RS07490 (1356082) 1356082..1356564 + 483 WP_000183505.1 GyrI-like domain-containing protein -
QUE37_RS07495 (1356769) 1356769..1357065 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
QUE37_RS07500 (1357067) 1357067..1357462 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
QUE37_RS07505 (1357595) 1357595..1359202 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
QUE37_RS07510 (1359340) 1359340..1361598 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T43789 WP_000415584.1 NZ_AP027404:1356769-1357065 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T43789 NZ_AP027404:1356769-1357065 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT43789 WP_000650107.1 NZ_AP027404:1357067-1357462 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT43789 NZ_AP027404:1357067-1357462 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References