Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 224070..224663 Replicon chromosome
Accession NZ_AP027370
Organism Hydrogenimonas sp. ISO32

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag QUD54_RS01100 Protein ID WP_286337118.1
Coordinates 224070..224351 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QUD54_RS01105 Protein ID WP_286337119.1
Coordinates 224364..224663 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUD54_RS01075 (HCR_02120) 219662..221440 + 1779 WP_286337114.1 amidohydrolase -
QUD54_RS01080 (HCR_02130) 221454..222251 + 798 WP_286337115.1 hypothetical protein -
QUD54_RS01085 (HCR_02140) 222260..222508 + 249 WP_286337116.1 hypothetical protein -
QUD54_RS01090 (HCR_02150) 222529..223776 + 1248 WP_286337117.1 hypothetical protein -
QUD54_RS01095 223947..224009 + 63 WP_286338052.1 hypothetical protein -
QUD54_RS01100 (HCR_02160) 224070..224351 + 282 WP_286337118.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QUD54_RS01105 (HCR_02170) 224364..224663 + 300 WP_286337119.1 HigA family addiction module antitoxin Antitoxin
QUD54_RS01110 (HCR_02180) 224879..225037 + 159 WP_286337120.1 hypothetical protein -
QUD54_RS01115 (HCR_02190) 225294..225986 - 693 WP_286337121.1 SprT family zinc-dependent metalloprotease -
QUD54_RS01120 (HCR_02200) 225987..228929 - 2943 WP_286337122.1 type I restriction endonuclease subunit R -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10643.24 Da        Isoelectric Point: 9.8875

>T43776 WP_286337118.1 NZ_AP027370:224070-224351 [Hydrogenimonas sp. ISO32]
MIKSFADRETKKFFQTGKSRKVPDTIHKAALRKLDYLNAAASLDDLRVPPGNMLEALTGDLKGKYSIRINQQYRIVFAFE
KGDAYDVSIMDYH

Download         Length: 282 bp

>T43776 NZ_AP027370:224070-224351 [Hydrogenimonas sp. ISO32]
ATGATAAAAAGTTTTGCGGATAGAGAAACGAAAAAGTTCTTCCAGACCGGTAAAAGTCGAAAGGTCCCCGACACGATCCA
CAAAGCCGCATTGCGCAAACTGGATTATCTGAATGCCGCCGCTTCGCTGGATGATCTGCGCGTACCGCCGGGCAATATGC
TCGAAGCACTCACCGGTGATCTGAAAGGCAAATACTCCATCCGCATCAACCAACAATATCGCATCGTCTTCGCTTTTGAA
AAGGGCGATGCGTACGATGTGTCGATCATGGATTATCATTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11286.00 Da        Isoelectric Point: 8.0263

>AT43776 WP_286337119.1 NZ_AP027370:224364-224663 [Hydrogenimonas sp. ISO32]
MNELQREPTHPGEILLEEFLKPLGLTQSALAKDLHTSFRAVNELVNGKRGITTEMALKLARYFGTTPQLWLNLQNSYDLY
RVGRKKADEIEAVKRCEVA

Download         Length: 300 bp

>AT43776 NZ_AP027370:224364-224663 [Hydrogenimonas sp. ISO32]
ATGAACGAGTTGCAAAGAGAACCTACCCATCCGGGTGAAATCCTTCTCGAAGAGTTTCTCAAACCCTTAGGTCTAACTCA
AAGTGCATTGGCCAAAGACCTGCACACCTCCTTTCGCGCCGTCAACGAACTGGTCAACGGCAAACGGGGCATCACCACCG
AAATGGCCCTGAAACTGGCCCGCTATTTCGGCACCACCCCGCAGCTTTGGCTAAACCTTCAAAACAGCTACGATCTTTAC
CGCGTCGGCAGGAAAAAGGCCGACGAGATCGAAGCGGTCAAACGATGTGAAGTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References