Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1312204..1312651 Replicon chromosome
Accession NZ_AP027369
Organism Cutibacterium avidum strain TP-CV302

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QUD49_RS06020 Protein ID WP_050796929.1
Coordinates 1312204..1312362 (+) Length 53 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QUD49_RS06025 Protein ID WP_231097104.1
Coordinates 1312397..1312651 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUD49_RS06000 1307358..1308233 + 876 WP_143045242.1 hypothetical protein -
QUD49_RS06005 (TPCV302_11750) 1308649..1309482 + 834 WP_021108764.1 hypothetical protein -
QUD49_RS06010 (TPCV302_11760) 1309765..1310355 + 591 WP_004811991.1 DUF3267 domain-containing protein -
QUD49_RS06015 (TPCV302_11770) 1311198..1311794 + 597 WP_023032456.1 hypothetical protein -
QUD49_RS06020 (TPCV302_11780) 1312204..1312362 + 159 WP_050796929.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QUD49_RS06025 (TPCV302_11790) 1312397..1312651 + 255 WP_231097104.1 HigA family addiction module antitoxin Antitoxin
QUD49_RS06030 (TPCV302_11800) 1312719..1313222 + 504 WP_021108760.1 GNAT family N-acetyltransferase -
QUD49_RS06035 (TPCV302_11810) 1313660..1313788 + 129 WP_260320465.1 hypothetical protein -
QUD49_RS06040 1314041..1314238 + 198 WP_235044102.1 CopG family transcriptional regulator -
QUD49_RS06045 (TPCV302_11830) 1314328..1314615 + 288 WP_235044101.1 alcohol dehydrogenase -
QUD49_RS06050 (TPCV302_11840) 1314728..1315102 - 375 WP_162141116.1 class I SAM-dependent methyltransferase -
QUD49_RS06055 (TPCV302_11850) 1315223..1315429 - 207 WP_004811983.1 cold-shock protein -
QUD49_RS06060 (TPCV302_11860) 1315659..1315928 + 270 WP_004811982.1 hypothetical protein -
QUD49_RS06065 (TPCV302_11870) 1316209..1317282 - 1074 WP_235044100.1 Fic family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1308302..1319318 11016


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-51)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(2-81)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 6129.88 Da        Isoelectric Point: 4.6286

>T43775 WP_050796929.1 NZ_AP027369:1312204-1312362 [Cutibacterium avidum]
MLEDLRVPPGNRLEALKGDRAGQHSIRINDQWRICFRWTDAGPEEVEIVDYY

Download         Length: 159 bp

>T43775 NZ_AP027369:1312204-1312362 [Cutibacterium avidum]
ATGCTCGAAGACCTCCGCGTTCCACCCGGTAACCGACTCGAGGCGCTCAAGGGCGACCGAGCTGGTCAGCACAGCATCAG
AATCAATGATCAGTGGCGGATCTGTTTCAGATGGACAGACGCCGGACCAGAGGAGGTGGAGATCGTTGACTACTACTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9242.49 Da        Isoelectric Point: 6.9879

>AT43775 WP_231097104.1 NZ_AP027369:1312397-1312651 [Cutibacterium avidum]
MEDFIEGFGITQHKLAVSIGVPPRRINEIVHGKRGISADTALRLAKYFGTSATFWTNVQSHYELDRAEHAAAEQIAAITP
LHVA

Download         Length: 255 bp

>AT43775 NZ_AP027369:1312397-1312651 [Cutibacterium avidum]
ATGGAGGATTTCATCGAGGGGTTCGGGATCACGCAGCACAAGCTCGCTGTGTCGATAGGTGTGCCGCCGCGGCGGATCAA
CGAGATCGTGCACGGCAAGCGAGGGATCTCAGCGGACACCGCATTGCGACTTGCGAAGTACTTCGGAACCTCGGCGACAT
TCTGGACCAATGTGCAGAGTCACTACGAGCTCGACCGTGCGGAACACGCGGCAGCTGAGCAGATCGCGGCGATCACGCCG
CTGCACGTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References