Detailed information of TA system TA043754

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1022335..1022561
• Replicon: chromosome
• Accession: NZ_AP027302
• Organism: Enterococcus faecalis strain N4E

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: QUD80_RS04910
• Protein ID: WP_224561205.1
• Coordinates: 1022335..1022436 (+)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1022381..1022561 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUD80_RS04895 (1018112)	1018112..1019008	-	897	WP_002368434.1	YitT family protein	-
QUD80_RS04900 (1019198)	1019198..1019704	-	507	WP_174114188.1	cysteine hydrolase family protein	-
QUD80_RS04905 (1019875)	1019875..1022145	+	2271	WP_002368430.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
QUD80_RS04910 (1022335)	1022335..1022436	+	102	WP_224561205.1	putative holin-like toxin	Toxin
- (1022381)	1022381..1022561	-	181	NuclAT_6	-	Antitoxin
- (1022385)	1022385..1022595	-	211	NuclAT_5	-	-
QUD80_RS04915 (1022770)	1022770..1022871	+	102	WP_021164441.1	putative holin-like toxin	-
- (1022816)	1022816..1022990	-	175	NuclAT_7	-	-
- (1022820)	1022820..1023027	-	208	NuclAT_4	-	-
QUD80_RS04920 (1023053)	1023053..1023505	-	453	WP_002354958.1	YueI family protein	-
QUD80_RS04925 (1023690)	1023690..1024637	+	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
QUD80_RS04930 (1024634)	1024634..1025599	+	966	WP_002354961.1	iron chelate uptake ABC transporter family permease subunit	-
QUD80_RS04935 (1025596)	1025596..1026351	+	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
QUD80_RS04940 (1026390)	1026390..1027343	+	954	WP_174114190.1	siderophore ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3629.37 Da
• Isoelectric Point: 4.5869

>T43754 WP_224561205.1 NZ_AP027302:1022335-1022436 [Enterococcus faecalis]
MSIEATLELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T43754 NZ_AP027302:1022335-1022436 [Enterococcus faecalis]
TTGTCAATCGAAGCGACATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin

Nucleotide

• Length: 181 bp

>AT43754 NZ_AP027302:c1022561-1022381 [Enterococcus faecalis]
TGAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAG
TTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATAC
CGAAAATCAGTAGTGCAACAA

Structures

Antitoxin