Detailed information of TA system TA043748

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 947533..947975
• Replicon: chromosome
• Accession: NZ_AP027302
• Organism: Enterococcus faecalis strain N4E

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: QUD80_RS04565
• Protein ID: WP_002392696.1
• Coordinates: 947832..947975 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	947533..947731 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUD80_RS04535 (944190)	944190..944744	+	555	WP_002354869.1	Maf family protein	-
QUD80_RS04540 (944877)	944877..945314	+	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
QUD80_RS04545 (945489)	945489..946460	+	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
QUD80_RS04550 (946513)	946513..946719	-	207	WP_258075960.1	CPBP family intramembrane metalloprotease	-
QUD80_RS04555 (946924)	946924..947049	+	126	WP_002383214.1	hypothetical protein	-
QUD80_RS04560 (947457)	947457..947600	+	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	-
- (947574)	947574..947719	-	146	NuclAT_14	-	-
- (947533)	947533..947731	-	199	NuclAT_9	-	Antitoxin
QUD80_RS04565 (947832)	947832..947975	+	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	Toxin
- (947908)	947908..948094	-	187	NuclAT_10	-	-
- (947949)	947949..948094	-	146	NuclAT_13	-	-
- (948141)	948141..948274	-	134	NuclAT_15	-	-
QUD80_RS04570 (948343)	948343..948993	-	651	WP_002354875.1	beta-phosphoglucomutase	-
QUD80_RS04575 (949008)	949008..951752	-	2745	WP_174113967.1	glycoside hydrolase family 65 protein	-
QUD80_RS04580 (952013)	952013..952726	+	714	WP_002354877.1	trehalose operon repressor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T43748 WP_002392696.1 NZ_AP027302:947832-947975 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

>T43748 NZ_AP027302:947832-947975 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 199 bp

>AT43748 NZ_AP027302:c947731-947533 [Enterococcus faecalis]
TTTTTAGGGAAATGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGA
CGGTGACCGATTATATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin