Detailed information of TA system TA043736

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 856241..856682
• Replicon: chromosome
• Accession: NZ_AP027302
• Organism: Enterococcus faecalis strain N4E

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: QUD80_RS04125
• Protein ID: WP_016619108.1
• Coordinates: 856241..856384 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	856481..856682 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUD80_RS04120 (851355)	851355..856046	+	4692	WP_174114070.1	WxL domain-containing protein	-
- (856048)	856048..856097	-	50	NuclAT_16	-	-
- (856047)	856047..856309	+	263	NuclAT_11	-	-
QUD80_RS04125 (856241)	856241..856384	-	144	WP_016619108.1	putative holin-like toxin	Toxin
- (856495)	856495..856641	+	147	NuclAT_12	-	-
- (856481)	856481..856682	+	202	NuclAT_8	-	Antitoxin
QUD80_RS04130 (856615)	856615..856758	-	144	WP_002389461.1	type I toxin-antitoxin system toxin PepG1	-
QUD80_RS04135 (857093)	857093..858709	-	1617	WP_174114069.1	phosphatase PAP2/LCP family protein	-
QUD80_RS04140 (859395)	859395..860033	+	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
QUD80_RS04145 (860200)	860200..861192	-	993	WP_002378862.1	biotin--[acetyl-CoA-carboxylase] ligase	-
QUD80_RS04150 (861331)	861331..861546	+	216	WP_002354768.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5191.13 Da
• Isoelectric Point: 8.6626

>T43736 WP_016619108.1 NZ_AP027302:c856384-856241 [Enterococcus faecalis]
MNVSTKTYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

>T43736 NZ_AP027302:c856384-856241 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAACCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 202 bp

>AT43736 NZ_AP027302:856481-856682 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Structures

Antitoxin