Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 663839..664101 Replicon chromosome
Accession NZ_AP027297
Organism Enterococcus faecalis strain L6D

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag QUD71_RS03225 Protein ID WP_002392696.1
Coordinates 663958..664101 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 663839..664025 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUD71_RS03210 659205..659918 - 714 WP_010820328.1 trehalose operon repressor -
QUD71_RS03215 660180..662924 + 2745 WP_025190014.1 glycosyl hydrolase family 65 protein -
QUD71_RS03220 662939..663589 + 651 WP_002367457.1 beta-phosphoglucomutase -
- 663839..664025 + 187 - - Antitoxin
QUD71_RS03225 663958..664101 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
QUD71_RS03230 664333..665304 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
QUD71_RS03235 665479..665916 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
QUD71_RS03240 666049..666603 - 555 WP_010820330.1 Maf family protein -
QUD71_RS03245 666628..668760 - 2133 WP_010820331.1 DNA mismatch repair endonuclease MutL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T43706 WP_002392696.1 NZ_AP027297:c664101-663958 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

>T43706 NZ_AP027297:c664101-663958 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 187 bp

>AT43706 NZ_AP027297:663839-664025 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGCG
CAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References