Detailed information of TA system TA043703

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 590906..591131
• Replicon: chromosome
• Accession: NZ_AP027297
• Organism: Enterococcus faecalis strain L6D

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: QUD71_RS02865
• Protein ID: WP_075551663.1
• Coordinates: 591030..591131 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	590906..591085 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUD71_RS02835	586122..587075	-	954	WP_010820307.1	siderophore ABC transporter substrate-binding protein	-
QUD71_RS02840	587114..587869	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
QUD71_RS02845	587866..588831	-	966	WP_002367415.1	iron chelate uptake ABC transporter family permease subunit	-
QUD71_RS02850	588828..589775	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
QUD71_RS02855	589960..590412	+	453	WP_002354958.1	YueI family protein	-
QUD71_RS02860	590597..590698	-	102	WP_075551663.1	putative holin-like toxin	-
-	590906..591085	+	180	-	-	Antitoxin
QUD71_RS02865	591030..591131	-	102	WP_075551663.1	putative holin-like toxin	Toxin
QUD71_RS02870	591321..593591	-	2271	WP_002370088.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
QUD71_RS02875	593762..594268	+	507	WP_010820308.1	cysteine hydrolase family protein	-
QUD71_RS02880	594458..595354	+	897	WP_002354953.1	YitT family protein	-
QUD71_RS02885	595405..595803	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T43703 WP_075551663.1 NZ_AP027297:c591131-591030 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T43703 NZ_AP027297:c591131-591030 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin

Nucleotide

• Length: 180 bp

>AT43703 NZ_AP027297:590906-591085 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Structures

Antitoxin