Detailed information of TA system TA043693

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-YefM
• Location: 3370046..3370548
• Replicon: chromosome
• Accession: NZ_AP027292
• Organism: Neptuniibacter halophilus strain LMG 25378

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: QUD59_RS15760
• Protein ID: WP_286241044.1
• Coordinates: 3370285..3370548 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: QUD59_RS15755
• Protein ID: WP_286238143.1
• Coordinates: 3370046..3370288 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUD59_RS15755	3370046..3370288	+	243	WP_286238143.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
QUD59_RS15760	3370285..3370548	+	264	WP_286241044.1	Txe/YoeB family addiction module toxin	Toxin
QUD59_RS15765	3370624..3371487	-	864	WP_286238144.1	aminotransferase class IV	-
QUD59_RS15770	3371838..3372713	-	876	WP_286238145.1	LysR family transcriptional regulator	-
QUD59_RS15775	3372816..3373664	-	849	WP_286238146.1	DUF4392 domain-containing protein	-
QUD59_RS15780	3373727..3374665	-	939	WP_286238147.1	biotin-dependent carboxyltransferase family protein	-
QUD59_RS15785	3374662..3375339	-	678	WP_286238148.1	5-oxoprolinase subunit PxpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 9995.69 Da
• Isoelectric Point: 10.5647

>T43693 WP_286241044.1 NZ_AP027292:3370285-3370548 [Neptuniibacter halophilus]
VTWTLVYTRHAQKDAKKLASAGLKQKAQALLAVLAEDPFRKPPPFEKLVGDLAGAYSRRINIQHRLVYQVLEAERVVKVL
RLWSHYE

Nucleotide

• Length: 264 bp

>T43693 NZ_AP027292:3370285-3370548 [Neptuniibacter halophilus]
GTGACATGGACGTTGGTTTATACCAGGCACGCTCAGAAAGATGCGAAAAAGCTTGCTTCTGCGGGCCTGAAACAGAAAGC
GCAGGCTTTGTTGGCGGTATTGGCTGAAGACCCTTTCCGCAAGCCGCCGCCTTTTGAAAAACTCGTTGGAGATCTGGCCG
GGGCTTACTCGCGGCGCATCAATATTCAACACCGGTTGGTCTATCAGGTGCTTGAAGCCGAGCGTGTAGTGAAGGTGCTT
CGGCTGTGGAGTCACTATGAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8964.94 Da
• Isoelectric Point: 4.1348

>AT43693 WP_286238143.1 NZ_AP027292:3370046-3370288 [Neptuniibacter halophilus]
MSGITATEARSNLYRLIDETAESHQPIHITGKRNKAVLVSEEDWSAIQETLYLLSVPGMRESIRDGMDTPAADCDEDLDW

Nucleotide

• Length: 243 bp

>AT43693 NZ_AP027292:3370046-3370288 [Neptuniibacter halophilus]
ATGAGCGGAATTACAGCCACTGAAGCTCGCAGTAATCTTTACCGGCTGATTGATGAAACCGCAGAGTCACATCAGCCTAT
TCACATAACGGGTAAGCGCAATAAAGCGGTGCTGGTATCTGAGGAGGACTGGTCGGCGATTCAGGAAACGCTCTATCTGC
TGTCTGTGCCCGGTATGCGTGAATCGATTCGGGATGGGATGGATACCCCGGCAGCCGACTGCGATGAGGACCTTGATTGG
TGA