Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 737621..738396 Replicon chromosome
Accession NZ_AP027263
Organism Klebsiella pneumoniae strain TA8711

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag QUE17_RS03690 Protein ID WP_004150910.1
Coordinates 737911..738396 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag QUE17_RS03685 Protein ID WP_004150912.1
Coordinates 737621..737914 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE17_RS03665 (KPTA8711_07130) 732829..733431 - 603 WP_002916735.1 short chain dehydrogenase -
QUE17_RS03670 (KPTA8711_07140) 733529..734440 + 912 WP_004188550.1 LysR family transcriptional regulator -
QUE17_RS03675 (KPTA8711_07150) 734441..735589 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
QUE17_RS03680 (KPTA8711_07160) 735600..736976 - 1377 WP_004217775.1 cystathionine beta-synthase -
QUE17_RS03685 (KPTA8711_07170) 737621..737914 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
QUE17_RS03690 (KPTA8711_07180) 737911..738396 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
QUE17_RS03695 (KPTA8711_07200) 739100..739693 + 594 WP_004188553.1 hypothetical protein -
QUE17_RS03700 (KPTA8711_07210) 739790..740006 + 217 Protein_727 transposase -
QUE17_RS03705 (KPTA8711_07220) 740806..741666 + 861 WP_023280554.1 DUF6387 family protein -
QUE17_RS03710 (KPTA8711_07230) 741882..742115 + 234 WP_021569619.1 AlpA family transcriptional regulator -
QUE17_RS03715 (KPTA8711_07240) 742127..742438 + 312 WP_087867147.1 hypothetical protein -
QUE17_RS03720 (KPTA8711_07250) 742451..742837 + 387 WP_004199724.1 hypothetical protein -
QUE17_RS03725 (KPTA8711_07260) 742854..743141 + 288 WP_080792789.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 739790..739942 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T43668 WP_004150910.1 NZ_AP027263:737911-738396 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T43668 NZ_AP027263:737911-738396 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT43668 WP_004150912.1 NZ_AP027263:737621-737914 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT43668 NZ_AP027263:737621-737914 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References