43610

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 279062..279603 Replicon chromosome
Accession NZ_AP027256
Organism Escherichia coli strain JNE141411

Toxin (Protein)


Gene name yafQ Uniprot ID E9TC49
Locus tag QUD91_RS01245 Protein ID WP_000615982.1
Coordinates 279062..279340 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag QUD91_RS01250 Protein ID WP_000729704.1
Coordinates 279343..279603 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUD91_RS01230 (276644) 276644..277222 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
QUD91_RS01235 (277428) 277428..278195 + 768 WP_000333380.1 class II glutamine amidotransferase -
QUD91_RS01240 (278166) 278166..278906 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QUD91_RS01245 (279062) 279062..279340 - 279 WP_000615982.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QUD91_RS01250 (279343) 279343..279603 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QUD91_RS01255 (279789) 279789..280562 + 774 WP_000543899.1 C40 family peptidase -
QUD91_RS01260 (280619) 280619..280975 - 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
QUD91_RS01265 (280968) 280968..281246 - 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
QUD91_RS01270 (281351) 281351..283063 - 1713 Protein_246 flagellar biosynthesis protein FlhA -
QUD91_RS01275 (283035) 283035..283820 + 786 WP_000207575.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10816.59 Da        Isoelectric Point: 10.0702

>T43610 WP_000615982.1 NZ_AP027256:c279340-279062 [Escherichia coli]
MIQRDIEYSGQFSKDVKVAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T43610 NZ_AP027256:c279340-279062 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAAGTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT43610 WP_000729704.1 NZ_AP027256:c279603-279343 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT43610 NZ_AP027256:c279603-279343 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6Z6

References