Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | DinJ-YafQ (relBE)/YafQ-RelB |
Location | 270054..270589 | Replicon | chromosome |
Accession | NZ_AP027197 | ||
Organism | Escherichia coli strain 02E060 |
Toxin (Protein)
Gene name | yafQ | Uniprot ID | A0A0F3UZU8 |
Locus tag | QMG97_RS01225 | Protein ID | WP_032183258.1 |
Coordinates | 270054..270341 (-) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | dinJ | Uniprot ID | S1EWQ0 |
Locus tag | QMG97_RS01230 | Protein ID | WP_000729704.1 |
Coordinates | 270329..270589 (-) | Length | 87 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QMG97_RS01210 (267636) | 267636..268214 | + | 579 | WP_000284050.1 | D-sedoheptulose 7-phosphate isomerase | - |
QMG97_RS01215 (268420) | 268420..269187 | + | 768 | WP_000333380.1 | class II glutamine amidotransferase | - |
QMG97_RS01220 (269158) | 269158..269898 | - | 741 | WP_001225679.1 | peptidoglycan meso-diaminopimelic acid protein amidase | - |
QMG97_RS01225 (270054) | 270054..270341 | - | 288 | WP_032183258.1 | type II toxin-antitoxin system mRNA interferase toxin YafQ | Toxin |
QMG97_RS01230 (270329) | 270329..270589 | - | 261 | WP_000729704.1 | type II toxin-antitoxin system antitoxin DinJ | Antitoxin |
QMG97_RS01235 (270775) | 270775..271548 | + | 774 | WP_000543897.1 | C40 family peptidase | - |
QMG97_RS01240 (271605) | 271605..271961 | - | 357 | WP_001030484.1 | type II toxin-antitoxin system HicB family antitoxin | - |
QMG97_RS01245 (271954) | 271954..272232 | - | 279 | WP_000598760.1 | type II toxin-antitoxin system HicA family toxin | - |
QMG97_RS01250 (272337) | 272337..274430 | - | 2094 | WP_001140806.1 | flagellar biosynthesis protein FlhA | - |
QMG97_RS01255 (274414) | 274414..275553 | - | 1140 | WP_000785656.1 | flagellar type III secretion system protein FlhB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11166.96 Da Isoelectric Point: 10.2267
>T43435 WP_032183258.1 NZ_AP027197:c270341-270054 [Escherichia coli]
IRNLNQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDK
LLRFERTGTHAALFG
IRNLNQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDK
LLRFERTGTHAALFG
Download Length: 288 bp
>T43435 NZ_AP027197:c270341-270054 [Escherichia coli]
ATTAGGAATTTAAATCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAA
GGATATGAATAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACC
CGCTGCAAGGTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAA
CTTTTACGATTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
ATTAGGAATTTAAATCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAA
GGATATGAATAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACC
CGCTGCAAGGTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAA
CTTTTACGATTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9391.77 Da Isoelectric Point: 5.0758
>AT43435 WP_000729704.1 NZ_AP027197:c270589-270329 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI
Download Length: 261 bp
>AT43435 NZ_AP027197:c270589-270329 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0F3UZU8 |
Antitoxin
Source | ID | Structure |
---|---|---|
PDB | 4ML0 | |
AlphaFold DB | A0A0E0Y6Z6 |