Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ralRA/- |
| Location | 2055873..2056244 | Replicon | chromosome |
| Accession | NZ_AP027191 | ||
| Organism | Escherichia coli strain 10153 | ||
Toxin (Protein)
| Gene name | ralR | Uniprot ID | A0A0D6ZRD3 |
| Locus tag | QMG89_RS11135 | Protein ID | WP_001443846.1 |
| Coordinates | 2056095..2056244 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | ralA | ||
| Locus tag | - | ||
| Coordinates | 2055873..2056051 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMG89_RS11105 (2051625) | 2051625..2051798 | + | 174 | WP_001443847.1 | protein YnaL | - |
| QMG89_RS11110 (2051828) | 2051828..2053201 | + | 1374 | WP_000123745.1 | ATP-dependent RNA helicase DbpA | - |
| QMG89_RS11115 (2053330) | 2053330..2054265 | - | 936 | WP_001157407.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
| QMG89_RS11120 (2054317) | 2054317..2055552 | - | 1236 | WP_000040851.1 | site-specific integrase | - |
| QMG89_RS11125 (2055554) | 2055554..2055769 | - | 216 | WP_000079604.1 | excisionase XisR | - |
| - (2055873) | 2055873..2056051 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (2055873) | 2055873..2056051 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (2055873) | 2055873..2056051 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (2055873) | 2055873..2056051 | + | 179 | NuclAT_0 | - | Antitoxin |
| QMG89_RS11130 (2055869) | 2055869..2056057 | - | 189 | WP_001302840.1 | DUF1187 family protein | - |
| QMG89_RS11135 (2056095) | 2056095..2056244 | - | 150 | WP_001443846.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
| QMG89_RS11140 (2056300) | 2056300..2057109 | - | 810 | WP_000166313.1 | recombination protein RecT | - |
| QMG89_RS11145 (2057102) | 2057102..2059702 | - | 2601 | WP_000105151.1 | exodeoxyribonuclease VIII | - |
| QMG89_RS11150 (2059804) | 2059804..2060079 | - | 276 | WP_000632297.1 | protein RacC | - |
| QMG89_RS11155 (2060154) | 2060154..2060324 | - | 171 | WP_001352098.1 | YdaE family protein | - |
| QMG89_RS11160 (2060324) | 2060324..2060545 | - | 222 | WP_000560223.1 | killing protein KilR | - |
| QMG89_RS11165 (2060966) | 2060966..2061118 | - | 153 | WP_001427316.1 | DUF1391 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2022775..2098889 | 76114 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5383.12 Da Isoelectric Point: 8.3398
>T43402 WP_001443846.1 NZ_AP027191:c2056244-2056095 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER
Download Length: 150 bp
>T43402 NZ_AP027191:c2056244-2056095 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA
Antitoxin
Download Length: 179 bp
>AT43402 NZ_AP027191:2055873-2056051 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
