Detailed information of TA system TA043356

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 5671778..5672190
• Replicon: chromosome
• Accession: NZ_AP027185
• Organism: Escherichia coli strain NIID080884

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A0F3WCK2
• Locus tag: QMG74_RS28915
• Protein ID: WP_000132621.1
• Coordinates: 5671778..5672119 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	5672114..5672190 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMG74_RS28895 (5667788)	5667788..5669200	-	1413	WP_000199352.1	PLP-dependent aminotransferase family protein	-
QMG74_RS28900 (5669377)	5669377..5669541	+	165	WP_000394276.1	DUF1127 domain-containing protein	-
QMG74_RS28905 (5669638)	5669638..5670520	+	883	Protein_5644	DUF262 domain-containing protein	-
QMG74_RS28910 (5670568)	5670568..5671731	+	1164	WP_071531326.1	DUF1524 domain-containing protein	-
QMG74_RS28915 (5671778)	5671778..5672119	-	342	WP_000132621.1	endoribonuclease SymE	Toxin
- (5672114)	5672114..5672190	+	77	NuclAT_27	-	Antitoxin
- (5672114)	5672114..5672190	+	77	NuclAT_27	-	Antitoxin
- (5672114)	5672114..5672190	+	77	NuclAT_27	-	Antitoxin
- (5672114)	5672114..5672190	+	77	NuclAT_27	-	Antitoxin
- (5672114)	5672114..5672190	+	77	NuclAT_28	-	Antitoxin
- (5672114)	5672114..5672190	+	77	NuclAT_28	-	Antitoxin
- (5672114)	5672114..5672190	+	77	NuclAT_28	-	Antitoxin
- (5672114)	5672114..5672190	+	77	NuclAT_28	-	Antitoxin
QMG74_RS28920 (5672340)	5672340..5674109	-	1770	WP_000110079.1	restriction endonuclease subunit S	-
QMG74_RS28925 (5674109)	5674109..5675578	-	1470	WP_001341289.1	N-6 DNA methylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12342.12 Da
• Isoelectric Point: 7.8218

>T43356 WP_000132621.1 NZ_AP027185:c5672119-5671778 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPTAEESE
LMQSLRQVCKLSARKQKQVQDFIGVITGKQKVA

Nucleotide

• Length: 342 bp

>T43356 NZ_AP027185:c5672119-5671778 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCACCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTAATTAC
CGGTAAACAGAAAGTCGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT43356 NZ_AP027185:5672114-5672190 [Escherichia coli]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A0F3WCK2

Antitoxin