Detailed information of TA system TA043322

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 5691329..5691741
• Replicon: chromosome
• Accession: NZ_AP027181
• Organism: Escherichia coli strain 98E11

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A0F3WCK2
• Locus tag: QMG82_RS29250
• Protein ID: WP_000132621.1
• Coordinates: 5691329..5691670 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	5691665..5691741 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMG82_RS29230 (5687339)	5687339..5688751	-	1413	WP_000199352.1	PLP-dependent aminotransferase family protein	-
QMG82_RS29235 (5688928)	5688928..5689092	+	165	WP_000394276.1	DUF1127 domain-containing protein	-
QMG82_RS29240 (5689189)	5689189..5690071	+	883	Protein_5714	DUF262 domain-containing protein	-
QMG82_RS29245 (5690119)	5690119..5691282	+	1164	WP_071531326.1	DUF1524 domain-containing protein	-
QMG82_RS29250 (5691329)	5691329..5691670	-	342	WP_000132621.1	endoribonuclease SymE	Toxin
- (5691665)	5691665..5691741	+	77	NuclAT_28	-	Antitoxin
- (5691665)	5691665..5691741	+	77	NuclAT_28	-	Antitoxin
- (5691665)	5691665..5691741	+	77	NuclAT_28	-	Antitoxin
- (5691665)	5691665..5691741	+	77	NuclAT_28	-	Antitoxin
- (5691665)	5691665..5691741	+	77	NuclAT_29	-	Antitoxin
- (5691665)	5691665..5691741	+	77	NuclAT_29	-	Antitoxin
- (5691665)	5691665..5691741	+	77	NuclAT_29	-	Antitoxin
- (5691665)	5691665..5691741	+	77	NuclAT_29	-	Antitoxin
QMG82_RS29255 (5691891)	5691891..5693660	-	1770	WP_000110079.1	restriction endonuclease subunit S	-
QMG82_RS29260 (5693660)	5693660..5695129	-	1470	WP_001341289.1	N-6 DNA methylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12342.12 Da
• Isoelectric Point: 7.8218

>T43322 WP_000132621.1 NZ_AP027181:c5691670-5691329 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPTAEESE
LMQSLRQVCKLSARKQKQVQDFIGVITGKQKVA

Nucleotide

• Length: 342 bp

>T43322 NZ_AP027181:c5691670-5691329 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCACCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTAATTAC
CGGTAAACAGAAAGTCGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT43322 NZ_AP027181:5691665-5691741 [Escherichia coli]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A0F3WCK2

Antitoxin