Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ralRA/- |
| Location | 1869604..1869975 | Replicon | chromosome |
| Accession | NZ_AP027181 | ||
| Organism | Escherichia coli strain 98E11 | ||
Toxin (Protein)
| Gene name | ralR | Uniprot ID | A0A0D6ZRD3 |
| Locus tag | QMG82_RS09845 | Protein ID | WP_001443846.1 |
| Coordinates | 1869826..1869975 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | ralA | ||
| Locus tag | - | ||
| Coordinates | 1869604..1869782 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMG82_RS09815 (1865356) | 1865356..1865529 | + | 174 | WP_001443847.1 | protein YnaL | - |
| QMG82_RS09820 (1865559) | 1865559..1866932 | + | 1374 | WP_000123745.1 | ATP-dependent RNA helicase DbpA | - |
| QMG82_RS09825 (1867061) | 1867061..1867996 | - | 936 | WP_001157407.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
| QMG82_RS09830 (1868048) | 1868048..1869283 | - | 1236 | WP_000040851.1 | site-specific integrase | - |
| QMG82_RS09835 (1869285) | 1869285..1869500 | - | 216 | WP_000079604.1 | excisionase XisR | - |
| - (1869604) | 1869604..1869782 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1869604) | 1869604..1869782 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1869604) | 1869604..1869782 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1869604) | 1869604..1869782 | + | 179 | NuclAT_0 | - | Antitoxin |
| QMG82_RS09840 (1869600) | 1869600..1869788 | - | 189 | WP_001302840.1 | DUF1187 family protein | - |
| QMG82_RS09845 (1869826) | 1869826..1869975 | - | 150 | WP_001443846.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
| QMG82_RS09850 (1870031) | 1870031..1870840 | - | 810 | WP_000166313.1 | recombination protein RecT | - |
| QMG82_RS09855 (1870833) | 1870833..1873433 | - | 2601 | WP_000105151.1 | exodeoxyribonuclease VIII | - |
| QMG82_RS09860 (1873535) | 1873535..1873810 | - | 276 | WP_000632297.1 | protein RacC | - |
| QMG82_RS09865 (1873885) | 1873885..1874055 | - | 171 | WP_001352098.1 | YdaE family protein | - |
| QMG82_RS09870 (1874055) | 1874055..1874276 | - | 222 | WP_000560223.1 | killing protein KilR | - |
| QMG82_RS09875 (1874697) | 1874697..1874849 | - | 153 | WP_001427316.1 | DUF1391 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleC | 1868048..1965976 | 97928 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5383.12 Da Isoelectric Point: 8.3398
>T43295 WP_001443846.1 NZ_AP027181:c1869975-1869826 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER
Download Length: 150 bp
>T43295 NZ_AP027181:c1869975-1869826 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA
Antitoxin
Download Length: 179 bp
>AT43295 NZ_AP027181:1869604-1869782 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
