Detailed information of TA system TA043295

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1869604..1869975
• Replicon: chromosome
• Accession: NZ_AP027181
• Organism: Escherichia coli strain 98E11

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A0D6ZRD3
• Locus tag: QMG82_RS09845
• Protein ID: WP_001443846.1
• Coordinates: 1869826..1869975 (-)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1869604..1869782 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMG82_RS09815 (1865356)	1865356..1865529	+	174	WP_001443847.1	protein YnaL	-
QMG82_RS09820 (1865559)	1865559..1866932	+	1374	WP_000123745.1	ATP-dependent RNA helicase DbpA	-
QMG82_RS09825 (1867061)	1867061..1867996	-	936	WP_001157407.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
QMG82_RS09830 (1868048)	1868048..1869283	-	1236	WP_000040851.1	site-specific integrase	-
QMG82_RS09835 (1869285)	1869285..1869500	-	216	WP_000079604.1	excisionase XisR	-
- (1869604)	1869604..1869782	+	179	NuclAT_0	-	Antitoxin
- (1869604)	1869604..1869782	+	179	NuclAT_0	-	Antitoxin
- (1869604)	1869604..1869782	+	179	NuclAT_0	-	Antitoxin
- (1869604)	1869604..1869782	+	179	NuclAT_0	-	Antitoxin
QMG82_RS09840 (1869600)	1869600..1869788	-	189	WP_001302840.1	DUF1187 family protein	-
QMG82_RS09845 (1869826)	1869826..1869975	-	150	WP_001443846.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
QMG82_RS09850 (1870031)	1870031..1870840	-	810	WP_000166313.1	recombination protein RecT	-
QMG82_RS09855 (1870833)	1870833..1873433	-	2601	WP_000105151.1	exodeoxyribonuclease VIII	-
QMG82_RS09860 (1873535)	1873535..1873810	-	276	WP_000632297.1	protein RacC	-
QMG82_RS09865 (1873885)	1873885..1874055	-	171	WP_001352098.1	YdaE family protein	-
QMG82_RS09870 (1874055)	1874055..1874276	-	222	WP_000560223.1	killing protein KilR	-
QMG82_RS09875 (1874697)	1874697..1874849	-	153	WP_001427316.1	DUF1391 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	nleC	1868048..1965976	97928

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-48)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5383.12 Da
• Isoelectric Point: 8.3398

>T43295 WP_001443846.1 NZ_AP027181:c1869975-1869826 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER

Nucleotide

• Length: 150 bp

>T43295 NZ_AP027181:c1869975-1869826 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT43295 NZ_AP027181:1869604-1869782 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A0D6ZRD3

Antitoxin