Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1381770..1382565 Replicon chromosome
Accession NZ_AP027181
Organism Escherichia coli strain 98E11

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag QMG82_RS06980 Protein ID WP_000854914.1
Coordinates 1382191..1382565 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9LM11
Locus tag QMG82_RS06975 Protein ID WP_001280953.1
Coordinates 1381770..1382144 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMG82_RS06945 (1377125) 1377125..1378030 + 906 WP_000203541.1 diguanylate cyclase regulator RdcB family protein -
QMG82_RS06950 (1378027) 1378027..1379097 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
QMG82_RS06955 (1379437) 1379437..1380255 + 819 WP_001234682.1 DUF932 domain-containing protein -
QMG82_RS06960 (1380346) 1380346..1380831 + 486 WP_000214398.1 antirestriction protein -
QMG82_RS06965 (1380847) 1380847..1381323 + 477 WP_001186738.1 RadC family protein -
QMG82_RS06970 (1381386) 1381386..1381607 + 222 WP_000692323.1 DUF987 domain-containing protein -
QMG82_RS06975 (1381770) 1381770..1382144 + 375 WP_001280953.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QMG82_RS06980 (1382191) 1382191..1382565 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
QMG82_RS06985 (1382562) 1382562..1383053 + 492 WP_126347097.1 DUF5983 family protein -
QMG82_RS06990 (1383065) 1383065..1383262 + 198 WP_000839282.1 DUF957 domain-containing protein -
QMG82_RS06995 (1383347) 1383347..1384189 + 843 WP_001280481.1 DUF4942 domain-containing protein -
QMG82_RS07005 (1384660) 1384660..1385598 + 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
QMG82_RS07010 (1385653) 1385653..1386390 + 738 WP_000283664.1 zinc-binding phosphatase -
QMG82_RS07015 (1386414) 1386414..1386968 + 555 WP_001001902.1 molecular chaperone YcdY -
QMG82_RS07020 (1387070) 1387070..1387561 + 492 WP_001297187.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 1380847..1393125 12278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T43292 WP_000854914.1 NZ_AP027181:1382191-1382565 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T43292 NZ_AP027181:1382191-1382565 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13734.56 Da        Isoelectric Point: 6.6249

>AT43292 WP_001280953.1 NZ_AP027181:1381770-1382144 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPALATTS

Download         Length: 375 bp

>AT43292 NZ_AP027181:1381770-1382144 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACTCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LM11

References