Detailed information of TA system TA043278

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 5693328..5693740
• Replicon: chromosome
• Accession: NZ_AP027176
• Organism: Escherichia coli strain EH2252

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A0F3WCK2
• Locus tag: QMG71_RS29115
• Protein ID: WP_000132621.1
• Coordinates: 5693328..5693669 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	5693664..5693740 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMG71_RS29095 (5689338)	5689338..5690750	-	1413	WP_000199352.1	PLP-dependent aminotransferase family protein	-
QMG71_RS29100 (5690927)	5690927..5691091	+	165	WP_000394276.1	DUF1127 domain-containing protein	-
QMG71_RS29105 (5691188)	5691188..5692070	+	883	Protein_5694	DUF262 domain-containing protein	-
QMG71_RS29110 (5692118)	5692118..5693281	+	1164	WP_071531326.1	DUF1524 domain-containing protein	-
QMG71_RS29115 (5693328)	5693328..5693669	-	342	WP_000132621.1	endoribonuclease SymE	Toxin
- (5693664)	5693664..5693740	+	77	NuclAT_27	-	Antitoxin
- (5693664)	5693664..5693740	+	77	NuclAT_27	-	Antitoxin
- (5693664)	5693664..5693740	+	77	NuclAT_27	-	Antitoxin
- (5693664)	5693664..5693740	+	77	NuclAT_27	-	Antitoxin
- (5693664)	5693664..5693740	+	77	NuclAT_28	-	Antitoxin
- (5693664)	5693664..5693740	+	77	NuclAT_28	-	Antitoxin
- (5693664)	5693664..5693740	+	77	NuclAT_28	-	Antitoxin
- (5693664)	5693664..5693740	+	77	NuclAT_28	-	Antitoxin
QMG71_RS29120 (5693890)	5693890..5695659	-	1770	WP_000110079.1	restriction endonuclease subunit S	-
QMG71_RS29125 (5695659)	5695659..5697128	-	1470	WP_001341289.1	N-6 DNA methylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12342.12 Da
• Isoelectric Point: 7.8218

>T43278 WP_000132621.1 NZ_AP027176:c5693669-5693328 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPTAEESE
LMQSLRQVCKLSARKQKQVQDFIGVITGKQKVA

Nucleotide

• Length: 342 bp

>T43278 NZ_AP027176:c5693669-5693328 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCACCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTAATTAC
CGGTAAACAGAAAGTCGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT43278 NZ_AP027176:5693664-5693740 [Escherichia coli]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A0F3WCK2

Antitoxin