Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ralRA/- |
| Location | 1943306..1943677 | Replicon | chromosome |
| Accession | NZ_AP027176 | ||
| Organism | Escherichia coli strain EH2252 | ||
Toxin (Protein)
| Gene name | ralR | Uniprot ID | A0A0D6ZRD3 |
| Locus tag | QMG71_RS10260 | Protein ID | WP_001443846.1 |
| Coordinates | 1943528..1943677 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | ralA | ||
| Locus tag | - | ||
| Coordinates | 1943306..1943484 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMG71_RS10230 (1939058) | 1939058..1939231 | + | 174 | WP_001443847.1 | protein YnaL | - |
| QMG71_RS10235 (1939261) | 1939261..1940634 | + | 1374 | WP_000123745.1 | ATP-dependent RNA helicase DbpA | - |
| QMG71_RS10240 (1940763) | 1940763..1941698 | - | 936 | WP_001157407.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
| QMG71_RS10245 (1941750) | 1941750..1942985 | - | 1236 | WP_000040851.1 | site-specific integrase | - |
| QMG71_RS10250 (1942987) | 1942987..1943202 | - | 216 | WP_000079604.1 | excisionase XisR | - |
| - (1943306) | 1943306..1943484 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1943306) | 1943306..1943484 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1943306) | 1943306..1943484 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1943306) | 1943306..1943484 | + | 179 | NuclAT_0 | - | Antitoxin |
| QMG71_RS10255 (1943302) | 1943302..1943490 | - | 189 | WP_001302840.1 | DUF1187 family protein | - |
| QMG71_RS10260 (1943528) | 1943528..1943677 | - | 150 | WP_001443846.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
| QMG71_RS10265 (1943733) | 1943733..1944542 | - | 810 | WP_000166313.1 | recombination protein RecT | - |
| QMG71_RS10270 (1944535) | 1944535..1947135 | - | 2601 | WP_000105150.1 | exodeoxyribonuclease VIII | - |
| QMG71_RS10275 (1947237) | 1947237..1947512 | - | 276 | WP_000632297.1 | protein RacC | - |
| QMG71_RS10280 (1947587) | 1947587..1947757 | - | 171 | WP_001352098.1 | YdaE family protein | - |
| QMG71_RS10285 (1947757) | 1947757..1947978 | - | 222 | WP_000560223.1 | killing protein KilR | - |
| QMG71_RS10290 (1948399) | 1948399..1948551 | - | 153 | WP_001427316.1 | DUF1391 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1941750..1987689 | 45939 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5383.12 Da Isoelectric Point: 8.3398
>T43251 WP_001443846.1 NZ_AP027176:c1943677-1943528 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER
Download Length: 150 bp
>T43251 NZ_AP027176:c1943677-1943528 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA
Antitoxin
Download Length: 179 bp
>AT43251 NZ_AP027176:1943306-1943484 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
