Detailed information of TA system TA043234

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 5592629..5593041
• Replicon: chromosome
• Accession: NZ_AP027170
• Organism: Escherichia coli strain 20.1

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A0F3WCK2
• Locus tag: QMG87_RS28495
• Protein ID: WP_000132621.1
• Coordinates: 5592629..5592970 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	5592965..5593041 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMG87_RS28475 (5588639)	5588639..5590051	-	1413	WP_000199352.1	PLP-dependent aminotransferase family protein	-
QMG87_RS28480 (5590228)	5590228..5590392	+	165	WP_000394276.1	DUF1127 domain-containing protein	-
QMG87_RS28485 (5590489)	5590489..5591371	+	883	Protein_5569	DUF262 domain-containing protein	-
QMG87_RS28490 (5591419)	5591419..5592582	+	1164	WP_071531326.1	DUF1524 domain-containing protein	-
QMG87_RS28495 (5592629)	5592629..5592970	-	342	WP_000132621.1	endoribonuclease SymE	Toxin
- (5592965)	5592965..5593041	+	77	NuclAT_28	-	Antitoxin
- (5592965)	5592965..5593041	+	77	NuclAT_28	-	Antitoxin
- (5592965)	5592965..5593041	+	77	NuclAT_28	-	Antitoxin
- (5592965)	5592965..5593041	+	77	NuclAT_28	-	Antitoxin
- (5592965)	5592965..5593041	+	77	NuclAT_29	-	Antitoxin
- (5592965)	5592965..5593041	+	77	NuclAT_29	-	Antitoxin
- (5592965)	5592965..5593041	+	77	NuclAT_29	-	Antitoxin
- (5592965)	5592965..5593041	+	77	NuclAT_29	-	Antitoxin
QMG87_RS28500 (5593191)	5593191..5594960	-	1770	WP_000110079.1	restriction endonuclease subunit S	-
QMG87_RS28505 (5594960)	5594960..5596429	-	1470	WP_001341289.1	N-6 DNA methylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12342.12 Da
• Isoelectric Point: 7.8218

>T43234 WP_000132621.1 NZ_AP027170:c5592970-5592629 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPTAEESE
LMQSLRQVCKLSARKQKQVQDFIGVITGKQKVA

Nucleotide

• Length: 342 bp

>T43234 NZ_AP027170:c5592970-5592629 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCACCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTAATTAC
CGGTAAACAGAAAGTCGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT43234 NZ_AP027170:5592965-5593041 [Escherichia coli]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A0F3WCK2

Antitoxin