Detailed information of TA system TA043207

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1894307..1894678
• Replicon: chromosome
• Accession: NZ_AP027170
• Organism: Escherichia coli strain 20.1

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A0D6ZRD3
• Locus tag: QMG87_RS10040
• Protein ID: WP_001443846.1
• Coordinates: 1894529..1894678 (-)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1894307..1894485 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMG87_RS10010 (1890059)	1890059..1890232	+	174	WP_001443847.1	protein YnaL	-
QMG87_RS10015 (1890262)	1890262..1891635	+	1374	WP_000123745.1	ATP-dependent RNA helicase DbpA	-
QMG87_RS10020 (1891764)	1891764..1892699	-	936	WP_001157407.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
QMG87_RS10025 (1892751)	1892751..1893986	-	1236	WP_000040851.1	site-specific integrase	-
QMG87_RS10030 (1893988)	1893988..1894203	-	216	WP_000079604.1	excisionase XisR	-
- (1894307)	1894307..1894485	+	179	NuclAT_0	-	Antitoxin
- (1894307)	1894307..1894485	+	179	NuclAT_0	-	Antitoxin
- (1894307)	1894307..1894485	+	179	NuclAT_0	-	Antitoxin
- (1894307)	1894307..1894485	+	179	NuclAT_0	-	Antitoxin
QMG87_RS10035 (1894303)	1894303..1894491	-	189	WP_001302840.1	DUF1187 family protein	-
QMG87_RS10040 (1894529)	1894529..1894678	-	150	WP_001443846.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
QMG87_RS10045 (1894734)	1894734..1895543	-	810	WP_000166313.1	recombination protein RecT	-
QMG87_RS10050 (1895536)	1895536..1898136	-	2601	WP_000105150.1	exodeoxyribonuclease VIII	-
QMG87_RS10055 (1898238)	1898238..1898513	-	276	WP_000632297.1	protein RacC	-
QMG87_RS10060 (1898588)	1898588..1898758	-	171	WP_001352098.1	YdaE family protein	-
QMG87_RS10065 (1898758)	1898758..1898979	-	222	WP_000560223.1	killing protein KilR	-
QMG87_RS10070 (1899400)	1899400..1899552	-	153	WP_001427316.1	DUF1391 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	espX7/nleL	1861209..1942715	81506

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-48)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5383.12 Da
• Isoelectric Point: 8.3398

>T43207 WP_001443846.1 NZ_AP027170:c1894678-1894529 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER

Nucleotide

• Length: 150 bp

>T43207 NZ_AP027170:c1894678-1894529 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT43207 NZ_AP027170:1894307-1894485 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A0D6ZRD3

Antitoxin