Detailed information of TA system TA043193

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 5461151..5461563
• Replicon: chromosome
• Accession: NZ_AP027165
• Organism: Escherichia coli strain H19

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A0F3WCK2
• Locus tag: QMG77_RS27605
• Protein ID: WP_000132621.1
• Coordinates: 5461151..5461492 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	5461487..5461563 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMG77_RS27585 (5457161)	5457161..5458573	-	1413	WP_000199352.1	PLP-dependent aminotransferase family protein	-
QMG77_RS27590 (5458750)	5458750..5458914	+	165	WP_000394276.1	DUF1127 domain-containing protein	-
QMG77_RS27595 (5459011)	5459011..5459893	+	883	Protein_5398	DUF262 domain-containing protein	-
QMG77_RS27600 (5459941)	5459941..5461104	+	1164	WP_071531326.1	DUF1524 domain-containing protein	-
QMG77_RS27605 (5461151)	5461151..5461492	-	342	WP_000132621.1	endoribonuclease SymE	Toxin
- (5461487)	5461487..5461563	+	77	NuclAT_28	-	Antitoxin
- (5461487)	5461487..5461563	+	77	NuclAT_28	-	Antitoxin
- (5461487)	5461487..5461563	+	77	NuclAT_28	-	Antitoxin
- (5461487)	5461487..5461563	+	77	NuclAT_28	-	Antitoxin
- (5461487)	5461487..5461563	+	77	NuclAT_29	-	Antitoxin
- (5461487)	5461487..5461563	+	77	NuclAT_29	-	Antitoxin
- (5461487)	5461487..5461563	+	77	NuclAT_29	-	Antitoxin
- (5461487)	5461487..5461563	+	77	NuclAT_29	-	Antitoxin
QMG77_RS27610 (5461713)	5461713..5463482	-	1770	WP_000110079.1	restriction endonuclease subunit S	-
QMG77_RS27615 (5463482)	5463482..5464951	-	1470	WP_001341289.1	N-6 DNA methylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12342.12 Da
• Isoelectric Point: 7.8218

>T43193 WP_000132621.1 NZ_AP027165:c5461492-5461151 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPTAEESE
LMQSLRQVCKLSARKQKQVQDFIGVITGKQKVA

Nucleotide

• Length: 342 bp

>T43193 NZ_AP027165:c5461492-5461151 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCACCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTAATTAC
CGGTAAACAGAAAGTCGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT43193 NZ_AP027165:5461487-5461563 [Escherichia coli]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A0F3WCK2

Antitoxin