Detailed information of TA system TA043157

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 5654739..5655151
• Replicon: chromosome
• Accession: NZ_AP027162
• Organism: Escherichia coli strain EH031

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A0F3WCK2
• Locus tag: QMG85_RS28800
• Protein ID: WP_000132621.1
• Coordinates: 5654739..5655080 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	5655075..5655151 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMG85_RS28780 (5650749)	5650749..5652161	-	1413	WP_000199352.1	PLP-dependent aminotransferase family protein	-
QMG85_RS28785 (5652338)	5652338..5652502	+	165	WP_000394276.1	DUF1127 domain-containing protein	-
QMG85_RS28790 (5652599)	5652599..5653481	+	883	Protein_5633	DUF262 domain-containing protein	-
QMG85_RS28795 (5653529)	5653529..5654692	+	1164	WP_071531326.1	DUF1524 domain-containing protein	-
QMG85_RS28800 (5654739)	5654739..5655080	-	342	WP_000132621.1	endoribonuclease SymE	Toxin
- (5655075)	5655075..5655151	+	77	NuclAT_28	-	Antitoxin
- (5655075)	5655075..5655151	+	77	NuclAT_28	-	Antitoxin
- (5655075)	5655075..5655151	+	77	NuclAT_28	-	Antitoxin
- (5655075)	5655075..5655151	+	77	NuclAT_28	-	Antitoxin
- (5655075)	5655075..5655151	+	77	NuclAT_29	-	Antitoxin
- (5655075)	5655075..5655151	+	77	NuclAT_29	-	Antitoxin
- (5655075)	5655075..5655151	+	77	NuclAT_29	-	Antitoxin
- (5655075)	5655075..5655151	+	77	NuclAT_29	-	Antitoxin
QMG85_RS28805 (5655301)	5655301..5657070	-	1770	WP_000110079.1	restriction endonuclease subunit S	-
QMG85_RS28810 (5657070)	5657070..5658539	-	1470	WP_001341289.1	N-6 DNA methylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12342.12 Da
• Isoelectric Point: 7.8218

>T43157 WP_000132621.1 NZ_AP027162:c5655080-5654739 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPTAEESE
LMQSLRQVCKLSARKQKQVQDFIGVITGKQKVA

Nucleotide

• Length: 342 bp

>T43157 NZ_AP027162:c5655080-5654739 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCACCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTAATTAC
CGGTAAACAGAAAGTCGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT43157 NZ_AP027162:5655075-5655151 [Escherichia coli]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A0F3WCK2

Antitoxin