Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ralRA/- |
| Location | 1953307..1953678 | Replicon | chromosome |
| Accession | NZ_AP027162 | ||
| Organism | Escherichia coli strain EH031 | ||
Toxin (Protein)
| Gene name | ralR | Uniprot ID | A0A0D6ZRD3 |
| Locus tag | QMG85_RS10275 | Protein ID | WP_001443846.1 |
| Coordinates | 1953529..1953678 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | ralA | ||
| Locus tag | - | ||
| Coordinates | 1953307..1953485 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMG85_RS10245 (1949059) | 1949059..1949232 | + | 174 | WP_001443847.1 | protein YnaL | - |
| QMG85_RS10250 (1949262) | 1949262..1950635 | + | 1374 | WP_000123745.1 | ATP-dependent RNA helicase DbpA | - |
| QMG85_RS10255 (1950764) | 1950764..1951699 | - | 936 | WP_001157407.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
| QMG85_RS10260 (1951751) | 1951751..1952986 | - | 1236 | WP_000040851.1 | site-specific integrase | - |
| QMG85_RS10265 (1952988) | 1952988..1953203 | - | 216 | WP_000079604.1 | excisionase XisR | - |
| - (1953307) | 1953307..1953485 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1953307) | 1953307..1953485 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1953307) | 1953307..1953485 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1953307) | 1953307..1953485 | + | 179 | NuclAT_0 | - | Antitoxin |
| QMG85_RS10270 (1953303) | 1953303..1953491 | - | 189 | WP_001302840.1 | DUF1187 family protein | - |
| QMG85_RS10275 (1953529) | 1953529..1953678 | - | 150 | WP_001443846.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
| QMG85_RS10280 (1953734) | 1953734..1954543 | - | 810 | WP_000166313.1 | recombination protein RecT | - |
| QMG85_RS10285 (1954536) | 1954536..1957136 | - | 2601 | WP_000105150.1 | exodeoxyribonuclease VIII | - |
| QMG85_RS10290 (1957238) | 1957238..1957513 | - | 276 | WP_000632297.1 | protein RacC | - |
| QMG85_RS10295 (1957588) | 1957588..1957758 | - | 171 | WP_001352098.1 | YdaE family protein | - |
| QMG85_RS10300 (1957758) | 1957758..1957979 | - | 222 | WP_000560223.1 | killing protein KilR | - |
| QMG85_RS10305 (1958400) | 1958400..1958552 | - | 153 | WP_001427316.1 | DUF1391 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleC | 1951751..2044320 | 92569 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5383.12 Da Isoelectric Point: 8.3398
>T43130 WP_001443846.1 NZ_AP027162:c1953678-1953529 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER
Download Length: 150 bp
>T43130 NZ_AP027162:c1953678-1953529 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA
Antitoxin
Download Length: 179 bp
>AT43130 NZ_AP027162:1953307-1953485 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
