Detailed information of TA system TA043118

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 5627779..5628191
• Replicon: chromosome
• Accession: NZ_AP027159
• Organism: Escherichia coli strain 2313

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A0F3WCK2
• Locus tag: QMG94_RS28680
• Protein ID: WP_000132621.1
• Coordinates: 5627779..5628120 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	5628115..5628191 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMG94_RS28660 (5623789)	5623789..5625201	-	1413	WP_000199352.1	PLP-dependent aminotransferase family protein	-
QMG94_RS28665 (5625378)	5625378..5625542	+	165	WP_000394276.1	DUF1127 domain-containing protein	-
QMG94_RS28670 (5625639)	5625639..5626521	+	883	Protein_5611	DUF262 domain-containing protein	-
QMG94_RS28675 (5626569)	5626569..5627732	+	1164	WP_071531326.1	DUF1524 domain-containing protein	-
QMG94_RS28680 (5627779)	5627779..5628120	-	342	WP_000132621.1	endoribonuclease SymE	Toxin
- (5628115)	5628115..5628191	+	77	NuclAT_27	-	Antitoxin
- (5628115)	5628115..5628191	+	77	NuclAT_27	-	Antitoxin
- (5628115)	5628115..5628191	+	77	NuclAT_27	-	Antitoxin
- (5628115)	5628115..5628191	+	77	NuclAT_27	-	Antitoxin
- (5628115)	5628115..5628191	+	77	NuclAT_28	-	Antitoxin
- (5628115)	5628115..5628191	+	77	NuclAT_28	-	Antitoxin
- (5628115)	5628115..5628191	+	77	NuclAT_28	-	Antitoxin
- (5628115)	5628115..5628191	+	77	NuclAT_28	-	Antitoxin
QMG94_RS28685 (5628341)	5628341..5630110	-	1770	WP_000110079.1	restriction endonuclease subunit S	-
QMG94_RS28690 (5630110)	5630110..5631579	-	1470	WP_001341289.1	N-6 DNA methylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12342.12 Da
• Isoelectric Point: 7.8218

>T43118 WP_000132621.1 NZ_AP027159:c5628120-5627779 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPTAEESE
LMQSLRQVCKLSARKQKQVQDFIGVITGKQKVA

Nucleotide

• Length: 342 bp

>T43118 NZ_AP027159:c5628120-5627779 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCACCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTAATTAC
CGGTAAACAGAAAGTCGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT43118 NZ_AP027159:5628115-5628191 [Escherichia coli]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A0F3WCK2

Antitoxin