43021

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2623722..2624051 Replicon chromosome
Accession NZ_AP027136
Organism Enterococcus faecalis strain JARB-HU0796

Toxin (Protein)


Gene name txpA Uniprot ID A0A1J6YG70
Locus tag QUD94_RS12620 Protein ID WP_002396786.1
Coordinates 2623908..2624051 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2623722..2623797 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUD94_RS12600 (2619186) 2619186..2619401 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
QUD94_RS12605 (2619540) 2619540..2620532 + 993 WP_002394775.1 biotin--[acetyl-CoA-carboxylase] ligase -
QUD94_RS12610 (2620699) 2620699..2621337 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
QUD94_RS12615 (2622022) 2622022..2623638 + 1617 WP_010710855.1 phosphatase PAP2/LCP family protein -
- (2623722) 2623722..2623797 - 76 NuclAT_6 - Antitoxin
- (2623695) 2623695..2623811 - 117 NuclAT_8 - -
QUD94_RS12620 (2623908) 2623908..2624051 + 144 WP_002396786.1 putative holin-like toxin Toxin
- (2624195) 2624195..2624244 + 50 NuclAT_7 - -
- (2623983) 2623983..2624245 - 263 NuclAT_5 - -
QUD94_RS12625 (2624246) 2624246..2628937 - 4692 WP_010710853.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5203.19 Da        Isoelectric Point: 8.6626

>T43021 WP_002396786.1 NZ_AP027136:2623908-2624051 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Download         Length: 144 bp

>T43021 NZ_AP027136:2623908-2624051 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin


Download         Length: 76 bp

>AT43021 NZ_AP027136:c2623797-2623722 [Enterococcus faecalis]
TTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6YG70

Antitoxin

Download structure file

References