Detailed information of TA system TA043016

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2480904..2481165
• Replicon: chromosome
• Accession: NZ_AP027136
• Organism: Enterococcus faecalis strain JARB-HU0796

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: QUD94_RS11965
• Protein ID: WP_224561205.1
• Coordinates: 2481064..2481165 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2480904..2481115 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUD94_RS11940 (2476588)	2476588..2477541	-	954	WP_002359060.1	siderophore ABC transporter substrate-binding protein	-
QUD94_RS11945 (2477580)	2477580..2478335	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
QUD94_RS11950 (2478332)	2478332..2479297	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
QUD94_RS11955 (2479294)	2479294..2480241	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
QUD94_RS11960 (2480426)	2480426..2480878	+	453	WP_002378807.1	YueI family protein	-
- (2480904)	2480904..2481115	+	212	NuclAT_3	-	Antitoxin
- (2480941)	2480941..2481119	+	179	NuclAT_4	-	-
QUD94_RS11965 (2481064)	2481064..2481165	-	102	WP_224561205.1	putative holin-like toxin	Toxin
QUD94_RS11970 (2481356)	2481356..2483626	-	2271	WP_078122760.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
QUD94_RS11975 (2483797)	2483797..2484303	+	507	WP_002378810.1	cysteine hydrolase family protein	-
QUD94_RS11980 (2484493)	2484493..2485389	+	897	WP_002365354.1	YitT family protein	-
QUD94_RS11985 (2485440)	2485440..2485838	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3629.37 Da
• Isoelectric Point: 4.5869

>T43016 WP_224561205.1 NZ_AP027136:c2481165-2481064 [Enterococcus faecalis]
MSIEATLELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T43016 NZ_AP027136:c2481165-2481064 [Enterococcus faecalis]
TTGTCAATCGAAGCGACATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin

Nucleotide

• Length: 212 bp

>AT43016 NZ_AP027136:2480904-2481115 [Enterococcus faecalis]
TTCCATTTATAATAGAATTATGCTATTATGAAAATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAAC
ACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGG
TTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin