Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2517729..2518252 Replicon chromosome
Accession NZ_AP027135
Organism Staphylococcus aureus strain JP089

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag QMM73_RS12610 Protein ID WP_061838884.1
Coordinates 2517729..2517995 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag QMM73_RS12615 Protein ID WP_061838885.1
Coordinates 2517995..2518252 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMM73_RS12590 (2513036) 2513036..2514223 - 1188 WP_000026194.1 MFS transporter -
QMM73_RS12595 (2514619) 2514619..2515395 - 777 WP_061838882.1 iron export ABC transporter permease subunit FetB -
QMM73_RS12600 (2515388) 2515388..2516050 - 663 WP_043044946.1 ATP-binding cassette domain-containing protein -
QMM73_RS12605 (2516298) 2516298..2517374 - 1077 WP_001076671.1 M42 family metallopeptidase -
QMM73_RS12610 (2517729) 2517729..2517995 - 267 WP_061838884.1 Txe/YoeB family addiction module toxin Toxin
QMM73_RS12615 (2517995) 2517995..2518252 - 258 WP_061838885.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QMM73_RS12620 (2518610) 2518610..2519065 + 456 WP_000732076.1 DUF1307 domain-containing protein -
QMM73_RS12625 (2519233) 2519233..2520810 - 1578 WP_061838886.1 FMN-binding glutamate synthase family protein -
QMM73_RS12630 (2521005) 2521005..2521754 + 750 WP_061838887.1 CPBP family lipoprotein N-acylation protein LnsB -
QMM73_RS12635 (2521978) 2521978..2523171 - 1194 WP_000675406.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10698.38 Da        Isoelectric Point: 10.1384

>T43009 WP_061838884.1 NZ_AP027135:c2517995-2517729 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T43009 NZ_AP027135:c2517995-2517729 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9792.81 Da        Isoelectric Point: 4.1958

>AT43009 WP_061838885.1 NZ_AP027135:c2518252-2517995 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNTENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT43009 NZ_AP027135:c2518252-2517995 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATACCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References