Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2486537..2486721 Replicon chromosome
Accession NZ_AP027135
Organism Staphylococcus aureus strain JP089

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag QMM73_RS12470 Protein ID WP_000482652.1
Coordinates 2486614..2486721 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2486537..2486597 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMM73_RS12455 2481992..2482123 - 132 WP_223223631.1 hypothetical protein -
QMM73_RS12460 2482390..2484123 - 1734 WP_061838872.1 ABC transporter ATP-binding protein -
QMM73_RS12465 2484148..2485911 - 1764 WP_061838873.1 ABC transporter ATP-binding protein -
- 2486537..2486597 + 61 - - Antitoxin
QMM73_RS12470 2486614..2486721 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
QMM73_RS12475 2486855..2487241 - 387 WP_000779360.1 flippase GtxA -
QMM73_RS12480 2487509..2488651 + 1143 WP_061838874.1 glycerate kinase -
QMM73_RS12485 2488711..2489364 + 654 WP_053012342.1 hypothetical protein -
QMM73_RS12490 2489546..2490757 + 1212 WP_061838875.1 multidrug effflux MFS transporter -
QMM73_RS12495 2490880..2491353 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sbi / hlgA / hlgA / hlgC / hlgB 2469790..2487241 17451


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T43007 WP_000482652.1 NZ_AP027135:c2486721-2486614 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T43007 NZ_AP027135:c2486721-2486614 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT43007 NZ_AP027135:2486537-2486597 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References