Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2459657..2460174 Replicon chromosome
Accession NZ_AP027135
Organism Staphylococcus aureus strain JP089

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag QMM73_RS12325 Protein ID WP_000113262.1
Coordinates 2459657..2459923 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag QMM73_RS12330 Protein ID WP_061838810.1
Coordinates 2459923..2460174 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMM73_RS12295 (2455085) 2455085..2455621 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
QMM73_RS12300 (2455855) 2455855..2456679 - 825 WP_000572040.1 formate/nitrite transporter family protein -
QMM73_RS12305 (2456896) 2456896..2457078 - 183 WP_000230294.1 hypothetical protein -
QMM73_RS12310 (2457162) 2457162..2457629 - 468 WP_000153344.1 SRPBCC domain-containing protein -
QMM73_RS12315 (2457815) 2457815..2459362 - 1548 WP_061838809.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
QMM73_RS12320 (2459551) 2459551..2459622 - 72 Protein_2381 hypothetical protein -
QMM73_RS12325 (2459657) 2459657..2459923 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
QMM73_RS12330 (2459923) 2459923..2460174 - 252 WP_061838810.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QMM73_RS12335 (2460339) 2460339..2460440 - 102 Protein_2384 hypothetical protein -
QMM73_RS12340 (2460447) 2460447..2461046 - 600 WP_061838811.1 DsbA family protein -
QMM73_RS12345 (2461065) 2461065..2461427 - 363 WP_000819843.1 DUF4467 domain-containing protein -
QMM73_RS12350 (2461682) 2461682..2462932 + 1251 WP_061838812.1 FemA/FemB family glycyltransferase FmhA -
QMM73_RS12355 (2463029) 2463029..2463760 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
QMM73_RS12360 (2463757) 2463757..2464476 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-88)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T43006 WP_000113262.1 NZ_AP027135:c2459923-2459657 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T43006 NZ_AP027135:c2459923-2459657 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9463.63 Da        Isoelectric Point: 4.3407

>AT43006 WP_061838810.1 NZ_AP027135:c2460174-2459923 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSITDLERGKTITKD
IDV

Download         Length: 252 bp

>AT43006 NZ_AP027135:c2460174-2459923 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTACAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E


Antitoxin

Source ID Structure

References