Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2046177..2046591 Replicon chromosome
Accession NZ_AP027135
Organism Staphylococcus aureus strain JP089

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QMM73_RS10155 Protein ID WP_001065046.1
Coordinates 2046340..2046591 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QMM73_RS10150 Protein ID WP_000028424.1
Coordinates 2046177..2046350 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMM73_RS10100 (2042365) 2042365..2042709 - 345 WP_000402904.1 hypothetical protein -
QMM73_RS10105 (2042839) 2042839..2043138 - 300 WP_000988330.1 HNH endonuclease -
QMM73_RS10110 (2043370) 2043370..2043786 - 417 WP_000590122.1 hypothetical protein -
QMM73_RS10115 (2043814) 2043814..2044014 - 201 WP_000265043.1 DUF1514 family protein -
QMM73_RS10120 (2044014) 2044014..2044664 - 651 WP_001005262.1 hypothetical protein -
QMM73_RS10125 (2044823) 2044823..2044972 - 150 WP_000595265.1 transcriptional activator RinB -
QMM73_RS10130 (2044969) 2044969..2045175 - 207 WP_000195810.1 DUF1381 domain-containing protein -
QMM73_RS10135 (2045212) 2045212..2045718 - 507 WP_001061842.1 dUTPase -
QMM73_RS10140 (2045733) 2045733..2045894 - 162 WP_178135738.1 hypothetical protein -
QMM73_RS10145 (2046024) 2046024..2046176 - 153 WP_016170781.1 hypothetical protein -
QMM73_RS10150 (2046177) 2046177..2046350 - 174 WP_000028424.1 hypothetical protein Antitoxin
QMM73_RS10155 (2046340) 2046340..2046591 - 252 WP_001065046.1 DUF1024 family protein Toxin
QMM73_RS10160 (2046606) 2046606..2046848 - 243 WP_000131381.1 phi PVL orf 51-like protein -
QMM73_RS10165 (2046852) 2046852..2047220 - 369 WP_000101270.1 SA1788 family PVL leukocidin-associated protein -
QMM73_RS10170 (2047233) 2047233..2047637 - 405 WP_000401964.1 RusA family crossover junction endodeoxyribonuclease -
QMM73_RS10175 (2047646) 2047646..2047864 - 219 WP_000338528.1 hypothetical protein -
QMM73_RS10180 (2047871) 2047871..2048755 - 885 WP_031833239.1 DnaD domain protein -
QMM73_RS10185 (2048785) 2048785..2049255 - 471 WP_029549393.1 single-stranded DNA-binding protein -
QMM73_RS10190 (2049256) 2049256..2049873 - 618 WP_072507301.1 MBL fold metallo-hydrolase -
QMM73_RS10195 (2049954) 2049954..2050874 - 921 WP_274543942.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / chp / sak / hlb / groEL 2018820..2075950 57130


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9377.26 Da        Isoelectric Point: 3.7128

>T43001 WP_001065046.1 NZ_AP027135:c2046591-2046340 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T43001 NZ_AP027135:c2046591-2046340 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAATCAATTATCAGTGCTAGTGCCTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGGTTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT43001 WP_000028424.1 NZ_AP027135:c2046350-2046177 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT43001 NZ_AP027135:c2046350-2046177 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References