Detailed information of TA system TA042998

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2023163..2023470
• Replicon: chromosome
• Accession: NZ_AP027135
• Organism: Staphylococcus aureus strain JP089

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: QMM73_RS10000
• Protein ID: WP_072357969.1
• Coordinates: 2023294..2023470 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2023163..2023302 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMM73_RS09960 (2018507)	2018507..2018767	+	261	WP_001791826.1	hypothetical protein	-
QMM73_RS09965 (2018820)	2018820..2019170	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
QMM73_RS09970 (2019852)	2019852..2020301	+	450	WP_000727643.1	chemotaxis-inhibiting protein CHIPS	-
QMM73_RS09975 (2020394)	2020394..2020728	-	335	Protein_1926	SH3 domain-containing protein	-
QMM73_RS09980 (2021379)	2021379..2021870	-	492	WP_000920041.1	staphylokinase	-
QMM73_RS09985 (2022061)	2022061..2022816	-	756	WP_000861038.1	CHAP domain-containing protein	-
QMM73_RS09990 (2022828)	2022828..2023082	-	255	WP_000611512.1	phage holin	-
QMM73_RS09995 (2023134)	2023134..2023241	+	108	WP_031762631.1	hypothetical protein	-
- (2023163)	2023163..2023302	+	140	NuclAT_0	-	Antitoxin
- (2023163)	2023163..2023302	+	140	NuclAT_0	-	Antitoxin
- (2023163)	2023163..2023302	+	140	NuclAT_0	-	Antitoxin
- (2023163)	2023163..2023302	+	140	NuclAT_0	-	Antitoxin
QMM73_RS10000 (2023294)	2023294..2023470	-	177	WP_072357969.1	type I toxin-antitoxin system toxin PepG1	Toxin
QMM73_RS10005 (2023613)	2023613..2023987	-	375	WP_000340977.1	hypothetical protein	-
QMM73_RS10010 (2024043)	2024043..2024330	-	288	WP_001262620.1	hypothetical protein	-
QMM73_RS10015 (2024376)	2024376..2024528	-	153	WP_001000058.1	hypothetical protein	-
QMM73_RS10020 (2024521)	2024521..2028303	-	3783	WP_000582177.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2018820..2075950	57130

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T42998 WP_072357969.1 NZ_AP027135:c2023470-2023294 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T42998 NZ_AP027135:c2023470-2023294 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT42998 NZ_AP027135:2023163-2023302 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin