Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 820976..821390 Replicon chromosome
Accession NZ_AP027135
Organism Staphylococcus aureus strain JP089

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QMM73_RS03950 Protein ID WP_001065064.1
Coordinates 820976..821227 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QMM73_RS03955 Protein ID WP_000028424.1
Coordinates 821217..821390 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMM73_RS03895 (816232) 816232..816849 + 618 WP_072507301.1 MBL fold metallo-hydrolase -
QMM73_RS03900 (816850) 816850..817320 + 471 WP_029549393.1 single-stranded DNA-binding protein -
QMM73_RS03905 (817350) 817350..818234 + 885 WP_031833239.1 DnaD domain protein -
QMM73_RS03910 (818241) 818241..818459 + 219 WP_000338528.1 hypothetical protein -
QMM73_RS03915 (818468) 818468..818923 + 456 WP_281961767.1 RusA family crossover junction endodeoxyribonuclease -
QMM73_RS03920 (818936) 818936..819304 + 369 WP_000101270.1 SA1788 family PVL leukocidin-associated protein -
QMM73_RS03925 (819308) 819308..819550 + 243 WP_000132200.1 SAV1978 family virulence-associated passenger protein -
QMM73_RS03930 (819565) 819565..819771 + 207 WP_000676977.1 hypothetical protein -
QMM73_RS03935 (819774) 819774..820175 + 402 WP_052995681.1 hypothetical protein -
QMM73_RS03940 (820172) 820172..820621 + 450 WP_052995682.1 YopX family protein -
QMM73_RS03945 (820618) 820618..820983 + 366 WP_061839023.1 hypothetical protein -
QMM73_RS03950 (820976) 820976..821227 + 252 WP_001065064.1 DUF1024 family protein Toxin
QMM73_RS03955 (821217) 821217..821390 + 174 WP_000028424.1 hypothetical protein Antitoxin
QMM73_RS03960 (821391) 821391..821552 + 162 WP_000889680.1 hypothetical protein -
QMM73_RS03965 (821567) 821567..822100 + 534 WP_061839007.1 dUTPase -
QMM73_RS03970 (822137) 822137..822310 + 174 WP_001209216.1 hypothetical protein -
QMM73_RS03975 (822327) 822327..822467 + 141 Protein_770 DUF1381 domain-containing protein -
QMM73_RS03980 (822607) 822607..822843 + 237 WP_061839005.1 hypothetical protein -
QMM73_RS03985 (822836) 822836..823222 + 387 WP_061839004.1 hypothetical protein -
QMM73_RS03990 (823219) 823219..823392 + 174 WP_031870437.1 transcriptional activator RinB -
QMM73_RS03995 (823393) 823393..823794 + 402 WP_000286968.1 hypothetical protein -
QMM73_RS04000 (824148) 824148..824642 + 495 WP_000594088.1 terminase small subunit -
QMM73_RS04005 (824635) 824635..825858 + 1224 WP_001037578.1 PBSX family phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - clfA / vWbp 807378..882504 75126


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9377.26 Da        Isoelectric Point: 3.7128

>T42995 WP_001065064.1 NZ_AP027135:820976-821227 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T42995 NZ_AP027135:820976-821227 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAATCAGTTATCAGTGCTAGCGCATATAACGGTAATGATACAGAGGGATTGCTAAA
AGAGATTGAGGACGTATATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT42995 WP_000028424.1 NZ_AP027135:821217-821390 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT42995 NZ_AP027135:821217-821390 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAATCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References