Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2507607..2508130 Replicon chromosome
Accession NZ_AP027134
Organism Staphylococcus aureus strain JP008

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag QMM94_RS12465 Protein ID WP_061838884.1
Coordinates 2507607..2507873 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag QMM94_RS12470 Protein ID WP_154283974.1
Coordinates 2507873..2508130 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMM94_RS12445 (2502816) 2502816..2504003 - 1188 WP_281961879.1 MFS transporter -
QMM94_RS12450 (2504399) 2504399..2505175 - 777 WP_154283971.1 iron export ABC transporter permease subunit FetB -
QMM94_RS12455 (2505168) 2505168..2505830 - 663 WP_154283972.1 ATP-binding cassette domain-containing protein -
QMM94_RS12460 (2506176) 2506176..2507252 - 1077 WP_154283973.1 M42 family metallopeptidase -
QMM94_RS12465 (2507607) 2507607..2507873 - 267 WP_061838884.1 Txe/YoeB family addiction module toxin Toxin
QMM94_RS12470 (2507873) 2507873..2508130 - 258 WP_154283974.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QMM94_RS12475 (2508489) 2508489..2508944 + 456 WP_000732082.1 DUF1307 domain-containing protein -
QMM94_RS12480 (2509112) 2509112..2510689 - 1578 WP_154283975.1 FMN-binding glutamate synthase family protein -
QMM94_RS12485 (2510884) 2510884..2511633 + 750 WP_154284532.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10698.38 Da        Isoelectric Point: 10.1384

>T42994 WP_061838884.1 NZ_AP027134:c2507873-2507607 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T42994 NZ_AP027134:c2507873-2507607 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAACTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9784.84 Da        Isoelectric Point: 4.4205

>AT42994 WP_154283974.1 NZ_AP027134:c2508130-2507873 [Staphylococcus aureus]
MIITSPTEARKHFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT42994 NZ_AP027134:c2508130-2507873 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAGCATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGCTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References