Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2476394..2476578 Replicon chromosome
Accession NZ_AP027134
Organism Staphylococcus aureus strain JP008

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag QMM94_RS12325 Protein ID WP_000482647.1
Coordinates 2476471..2476578 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2476394..2476454 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMM94_RS12300 2471946..2473061 - 1116 WP_154283952.1 pyridoxal phosphate-dependent aminotransferase family protein -
QMM94_RS12305 2473039..2474046 - 1008 WP_001046645.1 biotin synthase BioB -
QMM94_RS12310 2474048..2475406 - 1359 WP_154283953.1 adenosylmethionine--8-amino-7-oxononanoate transaminase -
QMM94_RS12315 2475384..2476070 - 687 WP_154283954.1 dethiobiotin synthase -
QMM94_RS12320 2476125..2476292 - 168 WP_281961878.1 hypothetical protein -
- 2476394..2476454 + 61 - - Antitoxin
QMM94_RS12325 2476471..2476578 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
QMM94_RS12330 2476712..2477098 - 387 WP_000779356.1 flippase GtxA -
QMM94_RS12335 2477366..2478508 + 1143 WP_154283957.1 glycerate kinase -
QMM94_RS12340 2478568..2479227 + 660 WP_000831298.1 membrane protein -
QMM94_RS12345 2479408..2480619 + 1212 WP_154283958.1 multidrug effflux MFS transporter -
QMM94_RS12350 2480742..2481215 - 474 WP_154283959.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T42992 WP_000482647.1 NZ_AP027134:c2476578-2476471 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T42992 NZ_AP027134:c2476578-2476471 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT42992 NZ_AP027134:2476394-2476454 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTATTGCCCTAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References