Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2455049..2455566 | Replicon | chromosome |
| Accession | NZ_AP027134 | ||
| Organism | Staphylococcus aureus strain JP008 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | QMM94_RS12200 | Protein ID | WP_000113262.1 |
| Coordinates | 2455049..2455315 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | QMM94_RS12205 | Protein ID | WP_000584499.1 |
| Coordinates | 2455315..2455566 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMM94_RS12170 (2450486) | 2450486..2451022 | - | 537 | WP_154284075.1 | GNAT family N-acetyltransferase | - |
| QMM94_RS12175 (2451256) | 2451256..2452080 | - | 825 | WP_000594640.1 | formate/nitrite transporter family protein | - |
| QMM94_RS12180 (2452283) | 2452283..2452465 | - | 183 | WP_267814136.1 | hypothetical protein | - |
| QMM94_RS12185 (2452552) | 2452552..2453019 | - | 468 | WP_000153345.1 | SRPBCC domain-containing protein | - |
| QMM94_RS12190 (2453205) | 2453205..2454755 | - | 1551 | WP_000727763.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| QMM94_RS12195 (2454943) | 2454943..2455014 | - | 72 | WP_223200558.1 | hypothetical protein | - |
| QMM94_RS12200 (2455049) | 2455049..2455315 | - | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| QMM94_RS12205 (2455315) | 2455315..2455566 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| QMM94_RS12210 (2455730) | 2455730..2455831 | - | 102 | Protein_2359 | hypothetical protein | - |
| QMM94_RS12215 (2455838) | 2455838..2456437 | - | 600 | WP_154284074.1 | DsbA family protein | - |
| QMM94_RS12220 (2456456) | 2456456..2456818 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| QMM94_RS12225 (2457073) | 2457073..2458323 | + | 1251 | WP_154284073.1 | FemA/FemB family glycyltransferase FmhA | - |
| QMM94_RS12230 (2458420) | 2458420..2459151 | - | 732 | WP_154284072.1 | amino acid ABC transporter ATP-binding protein | - |
| QMM94_RS12235 (2459148) | 2459148..2459867 | - | 720 | WP_154284071.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T42991 WP_000113262.1 NZ_AP027134:c2455315-2455049 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T42991 NZ_AP027134:c2455315-2455049 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT42991 WP_000584499.1 NZ_AP027134:c2455566-2455315 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT42991 NZ_AP027134:c2455566-2455315 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|