Detailed information of TA system TA042984

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2015380..2015687
• Replicon: chromosome
• Accession: NZ_AP027134
• Organism: Staphylococcus aureus strain JP008

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: QMM94_RS09840
• Protein ID: WP_011447039.1
• Coordinates: 2015511..2015687 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2015380..2015519 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMM94_RS09800 (2010719)	2010719..2010979	+	261	WP_001791826.1	hypothetical protein	-
QMM94_RS09805 (2011032)	2011032..2011382	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
QMM94_RS09810 (2012067)	2012067..2012516	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
QMM94_RS09815 (2012611)	2012611..2012946	-	336	Protein_1894	SH3 domain-containing protein	-
QMM94_RS09820 (2013596)	2013596..2014087	-	492	WP_000919350.1	staphylokinase	-
QMM94_RS09825 (2014278)	2014278..2015033	-	756	WP_000861038.1	CHAP domain-containing protein	-
QMM94_RS09830 (2015045)	2015045..2015299	-	255	WP_000611512.1	phage holin	-
QMM94_RS09835 (2015351)	2015351..2015458	+	108	WP_001791821.1	hypothetical protein	-
- (2015380)	2015380..2015519	+	140	NuclAT_0	-	Antitoxin
- (2015380)	2015380..2015519	+	140	NuclAT_0	-	Antitoxin
- (2015380)	2015380..2015519	+	140	NuclAT_0	-	Antitoxin
- (2015380)	2015380..2015519	+	140	NuclAT_0	-	Antitoxin
QMM94_RS09840 (2015511)	2015511..2015687	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
QMM94_RS09845 (2015837)	2015837..2016133	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
QMM94_RS09850 (2016191)	2016191..2016478	-	288	WP_001040261.1	hypothetical protein	-
QMM94_RS09855 (2016525)	2016525..2016677	-	153	WP_001153681.1	hypothetical protein	-
QMM94_RS09860 (2016667)	2016667..2020452	-	3786	WP_281961837.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	blaZ	map / hlb / scn / chp / sak / hlb / groEL / hld	1963260..2076765	113505

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T42984 WP_011447039.1 NZ_AP027134:c2015687-2015511 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T42984 NZ_AP027134:c2015687-2015511 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT42984 NZ_AP027134:2015380-2015519 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin