Detailed information of TA system TA042969

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 322027..322627
• Replicon: chromosome
• Accession: NZ_AP027055
• Organism: Limnohabitans sp. INBF002

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: QMG15_RS01675
• Protein ID: WP_281789195.1
• Coordinates: 322027..322311 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: QMG15_RS01680
• Protein ID: WP_281789196.1
• Coordinates: 322304..322627 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QMG15_RS01645 (LINBF2_03270)	317779..318477	-	699	WP_281789187.1	prepilin-type N-terminal cleavage/methylation domain-containing protein	-
QMG15_RS01650 (LINBF2_03280)	318477..318857	-	381	WP_281789188.1	type II secretion system minor pseudopilin GspI	-
QMG15_RS01655 (LINBF2_03290)	318854..319285	-	432	WP_281789189.1	prepilin-type N-terminal cleavage/methylation domain-containing protein	-
QMG15_RS01660 (LINBF2_03300)	319305..319745	-	441	WP_281789190.1	type II secretion system major pseudopilin GspG	-
QMG15_RS01665	319749..320234	+	486	WP_281789192.1	type II secretion system protein N	-
QMG15_RS01670 (LINBF2_03330)	320279..321856	-	1578	WP_281789193.1	threonine ammonia-lyase, biosynthetic	-
QMG15_RS01675 (LINBF2_03340)	322027..322311	+	285	WP_281789195.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
QMG15_RS01680 (LINBF2_03350)	322304..322627	+	324	WP_281789196.1	helix-turn-helix transcriptional regulator	Antitoxin
QMG15_RS01685 (LINBF2_03360)	322775..323224	+	450	WP_281789197.1	OsmC family protein	-
QMG15_RS01690 (LINBF2_03370)	323234..323863	-	630	WP_281789198.1	2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone monooxygenase	-
QMG15_RS01695 (LINBF2_03380)	323937..325316	+	1380	WP_281789199.1	porin	-
QMG15_RS01700 (LINBF2_03390)	325420..326142	+	723	WP_281789200.1	OmpW family outer membrane protein	-
QMG15_RS01705 (LINBF2_03400)	326383..327594	+	1212	WP_281789201.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (2-89)

Antitoxin

• Cro/C1-type helix-turn-helix domain (48-102)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10670.69 Da
• Isoelectric Point: 10.3927

>T42969 WP_281789195.1 NZ_AP027055:322027-322311 [Limnohabitans sp. INBF002]
MIDKWPVGIYASFVRIAEQMVVSGPNLGMPYTRAMDDGLYEIRARGLEGIGRAFFCCIKGRRVVILHGFVKKTQATPIKE
LRLAKQRMKEVLND

Nucleotide

• Length: 285 bp

>T42969 NZ_AP027055:322027-322311 [Limnohabitans sp. INBF002]
TTGATTGATAAATGGCCTGTCGGCATTTACGCCAGTTTTGTGCGTATCGCTGAGCAAATGGTGGTCAGTGGGCCTAACCT
GGGCATGCCCTACACAAGGGCCATGGACGATGGTTTGTATGAAATTCGGGCGCGTGGCCTTGAGGGCATTGGTCGGGCGT
TCTTTTGCTGCATCAAGGGGCGTCGCGTGGTCATCTTGCATGGTTTTGTGAAAAAGACCCAAGCCACCCCGATCAAAGAA
CTTCGACTGGCCAAACAACGAATGAAAGAGGTGTTGAATGACTAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11603.37 Da
• Isoelectric Point: 10.6536

>AT42969 WP_281789196.1 NZ_AP027055:322304-322627 [Limnohabitans sp. INBF002]
MTKATQAQFKPVAFNPKQTAAQKRAADPAFQKAYDALEDEFAALAELLKARKEAGLTQADVAQRMGVSQPVLARIESSLG
SRNHAPSLSTLRRYAQACGKRLVISMV

Nucleotide

• Length: 324 bp

>AT42969 NZ_AP027055:322304-322627 [Limnohabitans sp. INBF002]
ATGACTAAGGCAACCCAAGCGCAATTTAAGCCTGTTGCTTTCAATCCGAAGCAAACAGCGGCACAAAAACGTGCGGCTGA
TCCTGCTTTTCAAAAAGCATACGACGCGTTAGAAGACGAATTTGCTGCATTGGCTGAGCTACTTAAGGCGCGTAAAGAAG
CAGGCTTAACGCAAGCGGATGTGGCCCAGCGCATGGGGGTGAGTCAACCTGTGCTGGCGCGTATTGAATCTAGCTTGGGT
AGCCGCAATCACGCGCCTTCGCTCAGTACCTTGCGTCGTTACGCGCAGGCGTGTGGCAAACGCTTGGTGATCAGCATGGT
TTGA