Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4526721..4527475 Replicon chromosome
Accession NZ_AP026948
Organism Salmonella enterica strain SE20-72C-2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OO990_RS22205 Protein ID WP_264878675.1
Coordinates 4526721..4527032 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OO990_RS22210 Protein ID WP_001259009.1
Coordinates 4527029..4527475 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO990_RS22175 (SE2072C2_42540) 4522379..4523281 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
OO990_RS22180 (SE2072C2_42550) 4523278..4523913 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
OO990_RS22185 (SE2072C2_42560) 4523910..4524839 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
OO990_RS22190 (SE2072C2_42570) 4524886..4525176 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
OO990_RS22195 (SE2072C2_42580) 4525177..4525488 - 312 WP_001159631.1 cytotoxic translational repressor of toxin-antitoxin stability system -
OO990_RS22200 (SE2072C2_42590) 4525706..4526635 + 930 WP_001127691.1 alpha/beta hydrolase -
OO990_RS22205 (SE2072C2_42600) 4526721..4527032 + 312 WP_264878675.1 type II toxin-antitoxin system HigB family toxin Toxin
OO990_RS22210 (SE2072C2_42610) 4527029..4527475 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
OO990_RS22215 (SE2072C2_42620) 4527490..4528431 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
OO990_RS22220 (SE2072C2_42630) 4528476..4528913 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
OO990_RS22225 (SE2072C2_42640) 4528910..4529782 - 873 WP_000921423.1 virulence factor BrkB family protein -
OO990_RS22230 (SE2072C2_42650) 4529776..4530375 - 600 WP_000965695.1 glucose-1-phosphatase -
OO990_RS22235 (SE2072C2_42660) 4530566..4531369 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
OO990_RS22240 (SE2072C2_42670) 4531403..4532299 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12414.37 Da        Isoelectric Point: 9.5334

>T42919 WP_264878675.1 NZ_AP026948:4526721-4527032 [Salmonella enterica]
VHVISRKPFNEAILMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T42919 NZ_AP026948:4526721-4527032 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATACTCATGTATCCAAACCATGAGCTTGCCCTCACTGAGTTGCT
GAATGTTCTTGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT42919 WP_001259009.1 NZ_AP026948:4527029-4527475 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT42919 NZ_AP026948:4527029-4527475 [Salmonella enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References