Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 4526721..4527475 | Replicon | chromosome |
Accession | NZ_AP026948 | ||
Organism | Salmonella enterica strain SE20-72C-2 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | OO990_RS22205 | Protein ID | WP_264878675.1 |
Coordinates | 4526721..4527032 (+) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | OO990_RS22210 | Protein ID | WP_001259009.1 |
Coordinates | 4527029..4527475 (+) | Length | 149 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OO990_RS22175 (SE2072C2_42540) | 4522379..4523281 | + | 903 | WP_000331364.1 | formate dehydrogenase subunit beta | - |
OO990_RS22180 (SE2072C2_42550) | 4523278..4523913 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
OO990_RS22185 (SE2072C2_42560) | 4523910..4524839 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
OO990_RS22190 (SE2072C2_42570) | 4524886..4525176 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
OO990_RS22195 (SE2072C2_42580) | 4525177..4525488 | - | 312 | WP_001159631.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
OO990_RS22200 (SE2072C2_42590) | 4525706..4526635 | + | 930 | WP_001127691.1 | alpha/beta hydrolase | - |
OO990_RS22205 (SE2072C2_42600) | 4526721..4527032 | + | 312 | WP_264878675.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
OO990_RS22210 (SE2072C2_42610) | 4527029..4527475 | + | 447 | WP_001259009.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
OO990_RS22215 (SE2072C2_42620) | 4527490..4528431 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
OO990_RS22220 (SE2072C2_42630) | 4528476..4528913 | - | 438 | WP_000560974.1 | D-aminoacyl-tRNA deacylase | - |
OO990_RS22225 (SE2072C2_42640) | 4528910..4529782 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
OO990_RS22230 (SE2072C2_42650) | 4529776..4530375 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
OO990_RS22235 (SE2072C2_42660) | 4530566..4531369 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
OO990_RS22240 (SE2072C2_42670) | 4531403..4532299 | - | 897 | WP_001520529.1 | sugar kinase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12414.37 Da Isoelectric Point: 9.5334
>T42919 WP_264878675.1 NZ_AP026948:4526721-4527032 [Salmonella enterica]
VHVISRKPFNEAILMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAILMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T42919 NZ_AP026948:4526721-4527032 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATACTCATGTATCCAAACCATGAGCTTGCCCTCACTGAGTTGCT
GAATGTTCTTGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATACTCATGTATCCAAACCATGAGCTTGCCCTCACTGAGTTGCT
GAATGTTCTTGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16720.06 Da Isoelectric Point: 6.6451
>AT42919 WP_001259009.1 NZ_AP026948:4527029-4527475 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT42919 NZ_AP026948:4527029-4527475 [Salmonella enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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